PMID- 32765390
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to 
      Neurodevelopmental Disorders.
PG  - 575
LID - 10.3389/fneur.2020.00575 [doi]
LID - 575
AB  - Preterm-born infants frequently suffer from an array of neurological damage, 
      collectively termed encephalopathy of prematurity (EoP). They also have an 
      increased risk of presenting with a neurodevelopmental disorder (e.g., autism 
      spectrum disorder; attention deficit hyperactivity disorder) later in life. It is 
      hypothesized that it is the gray matter injury to the cortex, in addition to 
      white matter injury, in EoP that is responsible for the altered behavior and 
      cognition in these individuals. However, although it is established that gray 
      matter injury occurs in infants following preterm birth, the exact nature of 
      these changes is not fully elucidated. Here we will review the current state of 
      knowledge in this field, amalgamating data from both clinical and preclinical 
      studies. This will be placed in the context of normal processes of developmental 
      biology and the known pathophysiology of neurodevelopmental disorders. Novel 
      diagnostic and therapeutic tactics required integration of this information so 
      that in the future we can combine mechanism-based approaches with patient 
      stratification to ensure the most efficacious and cost-effective clinical 
      practice.
CI  - Copyright (c) 2020 Fleiss, Gressens and Stolp.
FAU - Fleiss, Bobbi
AU  - Fleiss B
AD  - School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 
      Australia.
AD  - Universite de Paris, NeuroDiderot, Inserm, Paris, France.
AD  - PremUP, Paris, France.
AD  - Centre for the Developing Brain, School of Biomedical Engineering and Imaging 
      Sciences, King's College London, London, United Kingdom.
FAU - Gressens, Pierre
AU  - Gressens P
AD  - Universite de Paris, NeuroDiderot, Inserm, Paris, France.
AD  - PremUP, Paris, France.
AD  - Centre for the Developing Brain, School of Biomedical Engineering and Imaging 
      Sciences, King's College London, London, United Kingdom.
FAU - Stolp, Helen B
AU  - Stolp HB
AD  - Centre for the Developing Brain, School of Biomedical Engineering and Imaging 
      Sciences, King's College London, London, United Kingdom.
AD  - Comparative Biomedical Sciences, Royal Veterinary College, London, United 
      Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200714
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7381224
OTO - NOTNLM
OT  - MRI
OT  - brain injury
OT  - development
OT  - functional activity
OT  - inflammation
OT  - neuropathology
OT  - preterm
OT  - synaptopathy
EDAT- 2020/08/09 06:00
MHDA- 2020/08/09 06:01
PMCR- 2020/07/14
CRDT- 2020/08/09 06:00
PHST- 2020/04/07 00:00 [received]
PHST- 2020/05/19 00:00 [accepted]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2020/08/09 06:01 [medline]
PHST- 2020/07/14 00:00 [pmc-release]
AID - 10.3389/fneur.2020.00575 [doi]
PST - epublish
SO  - Front Neurol. 2020 Jul 14;11:575. doi: 10.3389/fneur.2020.00575. eCollection 
      2020.