PMID- 32765522
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - The Role of Dendritic Cells During Infections Caused by Highly Prevalent Viruses.
PG  - 1513
LID - 10.3389/fimmu.2020.01513 [doi]
LID - 1513
AB  - Dendritic cells (DCs) are a type of innate immune cells with major relevance in 
      the establishment of an adaptive response, as they are responsible for the 
      activation of lymphocytes. Since their discovery, several reports of their role 
      during infectious diseases have been performed, highlighting their functions and 
      their mechanisms of action. DCs can be categorized into different subsets, and 
      each of these subsets expresses a wide arrange of receptors and molecules that 
      aid them in the clearance of invading pathogens. Interferon (IFN) is a cytokine 
      -a molecule of protein origin- strongly associated with antiviral immune 
      responses. This cytokine is secreted by different cell types and is fundamental 
      in the modulation of both innate and adaptive immune responses against viral 
      infections. Particularly, DCs are one of the most important immune cells that 
      produce IFN, with type I IFNs (alpha and beta) highlighting as the most important, as 
      they are associated with viral clearance. Type I IFN secretion can be induced via 
      different pathways, activated by various components of the virus, such as surface 
      proteins or genetic material. These molecules can trigger the activation of the 
      IFN pathway trough surface receptors, including IFNAR, TLR4, or some 
      intracellular receptors, such as TLR7, TLR9, and TLR3. Here, we discuss various 
      types of dendritic cells found in humans and mice; their contribution to the 
      activation of the antiviral response triggered by the secretion of IFN, through 
      different routes of the induction for this important antiviral cytokine; and as 
      to how DCs are involved in human infections that are considered highly frequent 
      nowadays.
CI  - Copyright (c) 2020 Soto, Galvez, Andrade, Pacheco, Bohmwald, Berrios, Bueno and 
      Kalergis.
FAU - Soto, Jorge A
AU  - Soto JA
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Galvez, Nicolas M S
AU  - Galvez NMS
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Andrade, Catalina A
AU  - Andrade CA
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Pacheco, Gaspar A
AU  - Pacheco GA
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Bohmwald, Karen
AU  - Bohmwald K
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Berrios, Roslye V
AU  - Berrios RV
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Bueno, Susan M
AU  - Bueno SM
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Kalergis, Alexis M
AU  - Kalergis AM
AD  - Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias 
      Biologicas, Instituto Milenio de Inmunologia e Inmunoterapia, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
AD  - Departamento de Endocrinologia, Facultad de Medicina, Instituto Milenio de 
      Inmunologia e Inmunoterapia, Pontificia Universidad Catolica de Chile, Santiago, 
      Chile.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200716
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Interferon Type I)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Interferon Type I/metabolism
MH  - Prevalence
MH  - Signal Transduction
MH  - Toll-Like Receptors/metabolism
MH  - Virus Diseases/epidemiology/*immunology
MH  - Viruses/*immunology
PMC - PMC7378533
OTO - NOTNLM
OT  - IFN
OT  - antiviral response
OT  - dendritic cells
OT  - immune response
OT  - viruses
EDAT- 2020/08/09 06:00
MHDA- 2021/04/20 06:00
PMCR- 2020/01/01
CRDT- 2020/08/09 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/06/09 00:00 [accepted]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.01513 [doi]
PST - epublish
SO  - Front Immunol. 2020 Jul 16;11:1513. doi: 10.3389/fimmu.2020.01513. eCollection 
      2020.