PMID- 32765696
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 20
IP  - 3
DP  - 2020 Sep
TI  - Curcumin protects bone biomechanical properties and microarchitecture in type 2 
      diabetic rats with osteoporosis via the TGFbeta/Smad2/3 pathway.
PG  - 2200-2208
LID - 10.3892/etm.2020.8943 [doi]
AB  - Type 2 diabetic osteoporosis (T2DOP) has become a common secondary cause of 
      osteoporosis that accelerates bone loss and leads to bone fractures. The aim of 
      the current study was to investigate the association between the 
      anti-osteoporotic effect of curcumin (Cur) and the transforming growth factor 
      (TGF)beta/Smads signaling pathway. Male Sprague-Dawley rats were used in the 
      experiments. The type 2 diabetes mellitus (T2DM) animals were treated with Cur 
      for 8 weeks and blood lipid markers, bone microstructure and bone biomechanics 
      were then evaluated. The mRNA expression levels of TGFbeta1, type I TGFbeta receptor 
      (TbetaRI), TbetaRII and Smad2/3 were determined using reverse 
      transcription-quantitative PCR (RT-qPCR) and immunohistochemistry. The body 
      weight of rats with type 2 diabetes-induced osteoporosis increased (P<0.05), 
      while the lipid (total cholesterol, triglyceride and low-density lipoprotein) and 
      fasting blood glucose levels were decreased by Cur (P<0.05). In addition, Cur 
      significantly improved bone biomechanical properties (maximum load, breaking 
      load, elastic load and the bone rigidity coefficient) and preserved bone 
      microarchitecture (P<0.05). The RT-qPCR and IHC results revealed that Cur 
      increased TGFbeta1, TbetaRI, TbetaRII and Smad2/3 expression levels and promoted Smad2/3 
      phosphorylation in bones. The present results also indicated that Cur regulated 
      lipid and glucose levels, improved bone biomechanical properties and preserved 
      bone microarchitecture, and that these effects may be mediated via TGFbeta/Smad2/3 
      pathway activation.
CI  - Copyright: (c) Liang et al.
FAU - Liang, Yanlong
AU  - Liang Y
AD  - Department of Basic Medicine, Zhaoqing Medical College, Zhaoqing, Guangdong 
      526020, P.R. China.
AD  - School of Computer Science and Software, Zhaoqing College, Zhaoqing, Guangdong 
      526061, P.R. China.
FAU - Zhu, Benben
AU  - Zhu B
AD  - Department of Pharmacy, Affiliated People's Hospital of Inner Mongolia Medical 
      University, Hohhot, Inner Mongolia 010050, P.R. China.
FAU - Li, Shuhui
AU  - Li S
AD  - Key Laboratory of Tropical Diseases, Faculty of Medicine, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510080, P.R. China.
FAU - Zhai, Yun
AU  - Zhai Y
AD  - Department of Basic Medicine, Zhaoqing Medical College, Zhaoqing, Guangdong 
      526020, P.R. China.
FAU - Yang, Yiqiu
AU  - Yang Y
AD  - Department of Basic Medicine, Zhaoqing Medical College, Zhaoqing, Guangdong 
      526020, P.R. China.
FAU - Bai, Zaixian
AU  - Bai Z
AD  - Department of Pharmacy, Affiliated People's Hospital of Inner Mongolia Medical 
      University, Hohhot, Inner Mongolia 010050, P.R. China.
FAU - Zeng, Yuan
AU  - Zeng Y
AD  - Department of Pharmacy, People's Hospital of Nanxiong, Shaoguan, Guangdong 
      512400, P.R. China.
FAU - Li, Dawei
AU  - Li D
AD  - Department of Orthopedics and Traumatology, The Fourth Affiliated Hospital of 
      Inner Mongolia Medical University, Baotou, Inner Mongolia 014030, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200625
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7401480
OTO - NOTNLM
OT  - bone biomechanics
OT  - bone microarchitecture
OT  - curcumin
OT  - osteoporosis
OT  - type 2 diabetes
EDAT- 2020/08/09 06:00
MHDA- 2020/08/09 06:01
PMCR- 2020/06/25
CRDT- 2020/08/09 06:00
PHST- 2019/09/18 00:00 [received]
PHST- 2020/04/24 00:00 [accepted]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2020/08/09 06:01 [medline]
PHST- 2020/06/25 00:00 [pmc-release]
AID - ETM-0-0-8943 [pii]
AID - 10.3892/etm.2020.8943 [doi]
PST - ppublish
SO  - Exp Ther Med. 2020 Sep;20(3):2200-2208. doi: 10.3892/etm.2020.8943. Epub 2020 Jun 
      25.