PMID- 32766661
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20211204
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 8
IP  - 35
DP  - 2020 Sep 21
TI  - Photo-triggered release of doxorubicin from liposomes formulated by amphiphilic 
      phthalocyanines for combination therapy to enhance antitumor efficacy.
PG  - 8022-8036
LID - 10.1039/d0tb01093f [doi]
AB  - Multidrug combination therapy based on drug delivery systems (DDSs) has great 
      potential for cancer treatment. Stimuli-sensitive DDSs further enhance 
      therapeutic efficacy by providing controllable drug delivery. Herein, the 
      phospholipid compound DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) was used 
      to construct thermosensitive liposomes to load the photosensitizer ZnPc(PEG)(4) 
      (zinc phthalocyanine substituted by tetraethylene glycol) for molecular imaging, 
      and photodynamic and photothermal therapy, together with doxorubicin (DOX) for 
      chemotherapy. Interestingly, ZnPc(PEG)(4) as an amphipathic molecule was found to 
      be important in the construction of the liposomes, and it provided liposomes with 
      improved stability. The thus-obtained liposomes ZnPc(PEG)(4):DOX@LiPOs were 
      demonstrated to have enhanced ROS production capacity, heat generation properties 
      and a photo-triggered doxorubicin release effect, and, in cellular experiments, 
      increased cytotoxicity and apoptotic cell proportions, compared to 
      ZnPc(PEG)(4)@LiPOs and DOX@LiPOs. ZnPc(PEG)(4) loaded in lipid bilayers showed 
      stronger intracellular ROS production ability compared to free ZnPc(PEG)(4). In 
      vivo studies indicated that ZnPc(PEG)(4):DOX@LiPOs exhibited enhanced tumor 
      accumulation, increased anti-cancer effects and reduced liver retention. These 
      photo-triggered liposomes constructed by the photosensitizer ZnPc(PEG)(4) can 
      also be used to package other cargo for combined target tumor therapy and 
      molecular imaging.
FAU - Zheng, Ke
AU  - Zheng K
AD  - Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life 
      Science, Ministry of Education, Chemical Engineering College, Qingdao University 
      of Science and Technology, Qingdao 266042, China. zhengke@qust.edu.cn 
      dingcaifeng@qust.edu.cn.
FAU - Liu, Hongyan
AU  - Liu H
FAU - Liu, Xinxin
AU  - Liu X
FAU - Jiang, Libin
AU  - Jiang L
FAU - Li, Linlin
AU  - Li L
FAU - Wu, Xianggen
AU  - Wu X
FAU - Guo, Nannan
AU  - Guo N
FAU - Ding, Caifeng
AU  - Ding C
FAU - Huang, Mingdong
AU  - Huang M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200807
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Indoles)
RN  - 0 (Isoindoles)
RN  - 0 (Liposomes)
RN  - 0 (Reactive Oxygen Species)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
RN  - V5PUF4VLGY (phthalocyanine)
SB  - IM
MH  - Antineoplastic Agents/*administration & dosage/*chemistry/pharmacology
MH  - Antineoplastic Combined Chemotherapy Protocols
MH  - Cell Line, Tumor
MH  - Doxorubicin/*administration & dosage/*chemistry/pharmacology
MH  - Humans
MH  - *Hydrophobic and Hydrophilic Interactions
MH  - Indoles/*chemistry
MH  - Isoindoles
MH  - *Light
MH  - Liposomes
MH  - Polyethylene Glycols/chemistry
MH  - Reactive Oxygen Species/metabolism
EDAT- 2020/08/09 06:00
MHDA- 2021/03/27 06:00
CRDT- 2020/08/09 06:00
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2020/08/09 06:00 [entrez]
AID - 10.1039/d0tb01093f [doi]
PST - ppublish
SO  - J Mater Chem B. 2020 Sep 21;8(35):8022-8036. doi: 10.1039/d0tb01093f. Epub 2020 
      Aug 7.