PMID- 32768376 OWN - NLM STAT- MEDLINE DCOM- 20210701 LR - 20210701 IS - 1538-9375 (Electronic) IS - 1525-8610 (Linking) VI - 22 IP - 4 DP - 2021 Apr TI - Effect of Various Exercises on Intrinsic Capacity in Older Adults With Subjective Cognitive Concerns. PG - 780-786.e2 LID - S1525-8610(20)30570-3 [pii] LID - 10.1016/j.jamda.2020.06.048 [doi] AB - OBJECTIVES: Physical activity is associated with improvement in overall health and well-being, but robust evidence with comprehensive assessment of general health is lacking. This study aimed to clarify the effects of physical activity on intrinsic capacity among community-dwelling older adults with subjective memory concerns. DESIGN: A single-blind randomized controlled trial compared aerobic training (AT), resistance training (RT), and combined training (AT+RT) programs for improving general health evaluated by intrinsic capacity. SETTING: Toyota, Japan. PARTICIPANTS: Residents (65-85 years old) who screened positive for subjective memory concerns using the Kihon checklist were invited for eligibility assessment. In total, 415 community-dwelling older adults were enrolled and randomized into the AT, RT, AT+RT, and control groups. METHODS: Participants in the intervention groups underwent a group training program and self-paced home training for 26 weeks. The control group received lectures about health promotion. Intrinsic capacity (IC), constructed based on locomotion, cognition, psychological function, and vitality domains, was used to assess general health at baseline, week 26, and week 52. Between-group differences were exhibited with Z-score change in individual domain and combination of all domains. RESULTS: At baseline, mean age of all participants (47% women) was 72.3 +/- 4.6 years, with a mean composited IC Z-score of -0.2 +/- 0.5. Overall, AT and RT improved composite IC Z-scores by 0.17 (95% confidence interval [CI] 0.03-0.30) and 0.17 (95% CI 0.05-0.28) at week 26, respectively, but the beneficial effects waned at week 52. No significant differences in composite IC Z-scores were found in the AT+RT group at weeks 26 and 52. CONCLUSIONS AND IMPLICATIONS: Twenty-six-week AT with self-paced home training and RT with self-paced home training improve IC among community-dwelling older adults with subjective memory concerns, but the benefits waned subsequently. It will be required to develop optimal interventions that have a continuous beneficial effect on IC among community-dwelling older adults. CI - Copyright (c) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved. FAU - Huang, Chi Hsien AU - Huang CH AD - Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi Prefecture, Japan; Department of Family Medicine, E-Da Hospital, Kaohsiung City, Taiwan, R.O.C.; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung City, Taiwan, R.O.C.; Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi Prefecture, Japan. FAU - Umegaki, Hiroyuki AU - Umegaki H AD - Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi Prefecture, Japan. FAU - Makino, Taeko AU - Makino T AD - Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi Prefecture, Japan. FAU - Uemura, Kazuki AU - Uemura K AD - Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi Prefecture, Japan. FAU - Hayashi, Takahiro AU - Hayashi T AD - Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi Prefecture, Japan. FAU - Kitada, Tomoharu AU - Kitada T AD - Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi Prefecture, Japan. FAU - Inoue, Aiko AU - Inoue A AD - Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi Prefecture, Japan. FAU - Shimada, Hiroyuki AU - Shimada H AD - Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan. FAU - Kuzuya, Masafumi AU - Kuzuya M AD - Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi Prefecture, Japan; Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi Prefecture, Japan. Electronic address: kuzuya@med.nagoya-u.ac.jp. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20200805 PL - United States TA - J Am Med Dir Assoc JT - Journal of the American Medical Directors Association JID - 100893243 SB - IM MH - Aged MH - Aged, 80 and over MH - Cognition MH - *Exercise MH - *Exercise Therapy MH - Female MH - Humans MH - Japan MH - Male MH - Single-Blind Method OTO - NOTNLM OT - Intrinsic capacity OT - cognition OT - exercise OT - healthy aging OT - physical training EDAT- 2020/08/10 06:00 MHDA- 2021/07/02 06:00 CRDT- 2020/08/10 06:00 PHST- 2020/04/15 00:00 [received] PHST- 2020/06/22 00:00 [revised] PHST- 2020/06/25 00:00 [accepted] PHST- 2020/08/10 06:00 [pubmed] PHST- 2021/07/02 06:00 [medline] PHST- 2020/08/10 06:00 [entrez] AID - S1525-8610(20)30570-3 [pii] AID - 10.1016/j.jamda.2020.06.048 [doi] PST - ppublish SO - J Am Med Dir Assoc. 2021 Apr;22(4):780-786.e2. doi: 10.1016/j.jamda.2020.06.048. Epub 2020 Aug 5.