PMID- 32768487
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20220531
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 118
DP  - 2020 Nov
TI  - Brain changes associated with negative symptoms in clinical high risk for 
      psychosis: A systematic review.
PG  - 367-383
LID - S0149-7634(20)30510-8 [pii]
LID - 10.1016/j.neubiorev.2020.07.041 [doi]
AB  - The negative symptoms of schizophrenia are linked to poorer functional outcomes 
      and decreases in quality of life, and are often the first to develop in 
      individuals who are at clinical high risk (CHR) for psychosis. However, the 
      accompanying neurobiological changes are poorly understood. Therefore, we 
      conducted a systematic review of the studies that have examined the brain metrics 
      associated with negative symptoms in those at CHR. Electronic databases were 
      searched from inception to August 2019. Studies were selected if they mentioned 
      negative symptoms in youth at CHR for psychosis, and brain imaging. Of 261 
      citations, 43 studies with 2144 CHR participants met inclusion criteria. Too few 
      studies were focused on the same brain regions using similar neuroimaging methods 
      to perform a meta-analysis, however, the results of this systematic review 
      suggest a relationship between negative symptom increases and decreases in grey 
      matter. The paucity of studies linking changes in brain structure and function 
      with negative symptoms in those at CHR suggests that future work should focus on 
      examining these relationships.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Metzak, Paul D
AU  - Metzak PD
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Cumming School of Medicine, 
      University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada; 
      Mathison Centre for Mental Health Research & Education, Hotchkiss Brain 
      Institute, University of Calgary, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, 
      Canada. Electronic address: paul.metzak@ucalgary.ca.
FAU - Devoe, Daniel J
AU  - Devoe DJ
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Cumming School of Medicine, 
      University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada; 
      Mathison Centre for Mental Health Research & Education, Hotchkiss Brain 
      Institute, University of Calgary, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, 
      Canada. Electronic address: djadevoe@ucalgary.ca.
FAU - Iwaschuk, Amanda
AU  - Iwaschuk A
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Cumming School of Medicine, 
      University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada; 
      Mathison Centre for Mental Health Research & Education, Hotchkiss Brain 
      Institute, University of Calgary, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, 
      Canada. Electronic address: ajiwasch@ucalgary.ca.
FAU - Braun, Amy
AU  - Braun A
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Cumming School of Medicine, 
      University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada; 
      Mathison Centre for Mental Health Research & Education, Hotchkiss Brain 
      Institute, University of Calgary, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, 
      Canada. Electronic address: amy.braun1@ucalgary.ca.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, Cumming School of Medicine, 
      University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada; 
      Mathison Centre for Mental Health Research & Education, Hotchkiss Brain 
      Institute, University of Calgary, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, 
      Canada. Electronic address: jmadding@ucalgary.ca.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20200806
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
MH  - Adolescent
MH  - Brain/diagnostic imaging
MH  - Humans
MH  - Neurobiology
MH  - *Psychotic Disorders
MH  - Quality of Life
MH  - *Schizophrenia
EDAT- 2020/08/10 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/10 06:00
PHST- 2020/03/17 00:00 [received]
PHST- 2020/07/21 00:00 [revised]
PHST- 2020/07/31 00:00 [accepted]
PHST- 2020/08/10 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/10 06:00 [entrez]
AID - S0149-7634(20)30510-8 [pii]
AID - 10.1016/j.neubiorev.2020.07.041 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2020 Nov;118:367-383. doi: 
      10.1016/j.neubiorev.2020.07.041. Epub 2020 Aug 6.