PMID- 32768993
OWN - NLM
STAT- MEDLINE
DCOM- 20210312
LR  - 20230412
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 215
DP  - 2020 Oct 1
TI  - The relationship between insomnia and the intensity of drinking in 
      treatment-seeking individuals with alcohol dependence.
PG  - 108189
LID - S0376-8716(20)30354-9 [pii]
LID - 10.1016/j.drugalcdep.2020.108189 [doi]
AB  - BACKGROUND: Although insomnia is highly prevalent in alcohol use disorders(AUD), 
      its associations with the severity of alcohol use, pre-existing psychiatric 
      comorbidities and psychosocial problems are understudied. The present study 
      evaluates the interplay between these factors using a structural equation model 
      (SEM). METHODS: We assessed baseline cross-sectional data on patients with AUD (N 
      = 123) recruited to a placebo-controlled medication trial. Severity of alcohol 
      use was measured by the Brief Michigan Alcoholism Screening Test (B-MAST). 
      Insomnia Severity Index was used to assess insomnia symptoms. The Hamilton scales 
      for Depression and Anxiety, Short Index of Problems and Timeline Follow Back 
      evaluated psychiatric symptoms, psychosocial consequences of drinking and level 
      of alcohol consumption respectively. We used logistic regression to evaluate the 
      association between insomnia and severity of alcohol use while controlling for 
      covariates. We constructed a SEM with observed variables to delineate the effect 
      of psychiatric symptoms, psychosocial factors and current alcohol use on the 
      pathway between alcohol use severity and insomnia. RESULTS: The sample was 
      predominately male(83.9 %), Black(54.6 %) and employed(60.0 %). About 45 % of the 
      participants reported moderate-severe insomnia.The association between insomnia 
      and B-MAST attenuated after adjustment for demographics, psychiatric symptoms and 
      psychosocial problems(OR[95 % CI] = 1.17(0.99-1.47). SEM findings demonstrated 
      that B-MAST and insomnia were linked to psychiatric symptoms (95 % 
      Asymptotic-Confidence Interval (ACI): 0.015-0.159, p < 0.05) but not to 
      psychosocial problems or current alcohol use. CONCLUSION: Among treatment-seeking 
      patients with AUD, psychiatric burden mediated the relationship between severity 
      of alcohol use and insomnia. Clinicians should screen for underlying psychiatric 
      disorders among treatment-seeking patients with AUD complaining of insomnia.
CI  - Published by Elsevier B.V.
FAU - Chaudhary, Ninad S
AU  - Chaudhary NS
AD  - University of Alabama at Birmingham School of Public Health, 1665 University 
      Blvd, Birmingham, AL, 35211, USA. Electronic address: ninadsc@uab.edu.
FAU - Wong, Maria M
AU  - Wong MM
AD  - Idaho State University, 921 S 8th Ave, Stop 8112, Pocatello, ID, 83209, USA.
FAU - Kolla, Bhanu Prakash
AU  - Kolla BP
AD  - Department of Psychiatry and Psychology, Mayo Clinic, 2nd ST SW, Rochester, MN, 
      55905, USA.
FAU - Kampman, Kyle M
AU  - Kampman KM
AD  - Department of Psychiatry, Perelman School of Medicine, 3400 Civic Center Blvd, 
      Philadelphia, PA, 19104, USA; Cpl. Michael J. Crescenz VA Medical Center, 3900 
      Woodland Ave, Philadelphia, PA, 19104, USA.
FAU - Chakravorty, Subhajit
AU  - Chakravorty S
AD  - Department of Psychiatry, Perelman School of Medicine, 3400 Civic Center Blvd, 
      Philadelphia, PA, 19104, USA; Cpl. Michael J. Crescenz VA Medical Center, 3900 
      Woodland Ave, Philadelphia, PA, 19104, USA. Electronic address: 
      Subhajit.Chakravorty@uphs.upenn.edu.
LA  - eng
GR  - U01 DK123813/DK/NIDDK NIH HHS/United States
GR  - IK2 CX000855/CX/CSRD VA/United States
GR  - I01 CX001957/CX/CSRD VA/United States
GR  - UG3 DA049694/DA/NIDA NIH HHS/United States
GR  - U34 DA045177/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20200723
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/psychology
MH  - Alcoholism/*epidemiology
MH  - Anxiety
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Sleep Initiation and Maintenance Disorders/complications/*epidemiology
PMC - PMC10082590
MID - NIHMS1616107
OTO - NOTNLM
OT  - Alcoholism
OT  - Insomnia
OT  - Psychiatric symptoms
OT  - Psychosocial factors
OT  - Sleep initiation and maintenance disorders
OT  - Structural equation modelling
COIS- Conflict of Interest: None of the authors reported any conflict of interest
EDAT- 2020/08/10 06:00
MHDA- 2021/03/13 06:00
PMCR- 2023/04/08
CRDT- 2020/08/10 06:00
PHST- 2019/12/05 00:00 [received]
PHST- 2020/06/16 00:00 [revised]
PHST- 2020/07/13 00:00 [accepted]
PHST- 2020/08/10 06:00 [pubmed]
PHST- 2021/03/13 06:00 [medline]
PHST- 2020/08/10 06:00 [entrez]
PHST- 2023/04/08 00:00 [pmc-release]
AID - S0376-8716(20)30354-9 [pii]
AID - 10.1016/j.drugalcdep.2020.108189 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2020 Oct 1;215:108189. doi: 
      10.1016/j.drugalcdep.2020.108189. Epub 2020 Jul 23.