PMID- 32771959
OWN - NLM
STAT- MEDLINE
DCOM- 20210825
LR  - 20211002
IS  - 1879-6265 (Electronic)
IS  - 1879-6257 (Print)
IS  - 1879-6257 (Linking)
VI  - 44
DP  - 2020 Oct
TI  - Harnessing virus tropism for dendritic cells for vaccine design.
PG  - 73-80
LID - S1879-6257(20)30055-9 [pii]
LID - 10.1016/j.coviro.2020.07.012 [doi]
AB  - Dendritic cells (DCs) are pivotal stimulators of T cell responses. They provide 
      essential signals (epitope presentation, proinflammatory cytokines, 
      co-stimulation) to T cells and prime adaptive immunity. Therefore, they are 
      paramount to immunization strategies geared to generate T cell immunity. The 
      inflammatory signals DCs respond to, classically occur in the context of acute 
      virus infection. Yet, enlisting viruses for engaging DCs is hampered by their 
      penchant for targeting DCs with sophisticated immune evasive and suppressive 
      ploys. In this review, we discuss our work on devising vectors based on a 
      recombinant polio:rhinovirus chimera for effectively targeting and engaging DCs. 
      We are juxtaposing this approach with commonly used, recently studied dsDNA virus 
      vector platforms.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Mosaheb, Mubeen M
AU  - Mosaheb MM
AD  - Departments of Molecular Genetics & Microbiology and Neurosurgery, Duke 
      University Medical School, MSRB1 Room 423, Box 3020 Durham, NC 27710, United 
      States.
FAU - Brown, Michael C
AU  - Brown MC
AD  - Departments of Molecular Genetics & Microbiology and Neurosurgery, Duke 
      University Medical School, MSRB1 Room 423, Box 3020 Durham, NC 27710, United 
      States.
FAU - Dobrikova, Elena Y
AU  - Dobrikova EY
AD  - Departments of Molecular Genetics & Microbiology and Neurosurgery, Duke 
      University Medical School, MSRB1 Room 423, Box 3020 Durham, NC 27710, United 
      States.
FAU - Dobrikov, Mikhail I
AU  - Dobrikov MI
AD  - Departments of Molecular Genetics & Microbiology and Neurosurgery, Duke 
      University Medical School, MSRB1 Room 423, Box 3020 Durham, NC 27710, United 
      States.
FAU - Gromeier, Matthias
AU  - Gromeier M
AD  - Departments of Molecular Genetics & Microbiology and Neurosurgery, Duke 
      University Medical School, MSRB1 Room 423, Box 3020 Durham, NC 27710, United 
      States. Electronic address: grome001@mc.duke.edu.
LA  - eng
GR  - F32 CA224593/CA/NCI NIH HHS/United States
GR  - R01 NS108773/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200806
PL  - Netherlands
TA  - Curr Opin Virol
JT  - Current opinion in virology
JID - 101560941
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Dendritic Cells/*immunology/virology
MH  - *Genetic Vectors
MH  - Humans
MH  - Immune Evasion
MH  - Immunity, Innate
MH  - Mice
MH  - Poliovirus/genetics/immunology
MH  - T-Lymphocytes/*immunology
MH  - *Viral Tropism
MH  - Viral Vaccines/*immunology
PMC - PMC7755660
MID - NIHMS1616425
COIS- Summary Declaration of Interest Statement. M.G. and M.C.B. are inventors of 
      intellectual property related to the discussed research that was licensed to 
      Istari Oncology, Inc. M.G. holds equity in-, and is an advisor and compensated 
      consultant of Istari Oncology, Inc.
EDAT- 2020/08/11 06:00
MHDA- 2021/08/26 06:00
PMCR- 2021/10/01
CRDT- 2020/08/11 06:00
PHST- 2020/07/09 00:00 [received]
PHST- 2020/07/17 00:00 [accepted]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2021/08/26 06:00 [medline]
PHST- 2020/08/11 06:00 [entrez]
PHST- 2021/10/01 00:00 [pmc-release]
AID - S1879-6257(20)30055-9 [pii]
AID - 10.1016/j.coviro.2020.07.012 [doi]
PST - ppublish
SO  - Curr Opin Virol. 2020 Oct;44:73-80. doi: 10.1016/j.coviro.2020.07.012. Epub 2020 
      Aug 6.