PMID- 32772633
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20210826
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 16
IP  - 10
DP  - 2020 Oct
TI  - Lighting chaperone-mediated autophagy (CMA) evolution with an ancient LAMP: the 
      existence of a functional CMA activity in fish.
PG  - 1918-1920
LID - 10.1080/15548627.2020.1797344 [doi]
AB  - Chaperone-mediated autophagy (CMA), as one of the main pathways of lysosomal 
      catabolism, plays essential roles for the maintenance of cellular homeostasis. To 
      date, the absence of any identifiable LAMP2A - the necessary and limiting protein 
      required for CMA - in non-tetrapod lineages, led to the paradigm that this 
      cellular process was restricted to mammals and birds. The recent findings of 
      Lescat et al., demonstrating the existence of a CMA activity in fish, now 
      reshuffle the cards regarding how the entire evolution of CMA function should be 
      considered and appreciated across metazoans. Hence, beyond challenging the 
      current tetrapod-centered accepted view, the work of Lescat et al. tackles the 
      possibility - or the compelling need - of using complementary and powerful 
      genetic models, such as zebrafish or medaka, for studying this fundamental 
      function from an evolutionary perspective.
FAU - Herpin, Amaury
AU  - Herpin A
AUID- ORCID: 0000-0002-0630-4027
AD  - INRAE, UR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu , 
      Rennes, France.
AD  - State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life 
      Sciences, Hunan Normal University , Changsha, Hunan, P. R. Of China.
FAU - Lescat, Laury
AU  - Lescat L
AD  - Department of Developmental and Molecular Biology and Department of Genetics, 
      Albert Einstein College of Medicine , New York, NY, USA.
FAU - Bobe, Julien
AU  - Bobe J
AUID- ORCID: 0000-0002-9355-8227
AD  - INRAE, UR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu , 
      Rennes, France.
FAU - Jenny, Andreas
AU  - Jenny A
AUID- ORCID: 0000-0001-5989-8212
AD  - Department of Developmental and Molecular Biology and Department of Genetics, 
      Albert Einstein College of Medicine , New York, NY, USA.
FAU - Seiliez, Iban
AU  - Seiliez I
AUID- ORCID: 0000-0002-2202-1756
AD  - Universite de Pau et des Pays de l'Adour, E2S UPPA, INRAE, UMR1419 Nutrition 
      Metabolisme et Aquaculture, F-64310 Saint-Pee-sur-Nivelle, France.
LA  - eng
GR  - R01 GM119160/GM/NIGMS NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200810
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (Molecular Chaperones)
SB  - IM
CON - Mol Biol Evol. 2020 Oct 1;37(10):2887-2899. PMID: 32437540
MH  - Animals
MH  - *Autophagy/genetics
MH  - *Chaperone-Mediated Autophagy
MH  - Lighting
MH  - Lysosomes
MH  - Molecular Chaperones/genetics
PMC - PMC8386616
OTO - NOTNLM
OT  - Chaperone-mediated autophagy
OT  - CMA
OT  - Lamp2a
OT  - evolution
OT  - fish
OT  - medaka
OT  - zebrafish
COIS- No potential conflict of interests was reported by the authors.
EDAT- 2020/08/11 06:00
MHDA- 2020/11/18 06:00
PMCR- 2021/08/10
CRDT- 2020/08/11 06:00
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/08/11 06:00 [entrez]
PHST- 2021/08/10 00:00 [pmc-release]
AID - 1797344 [pii]
AID - 10.1080/15548627.2020.1797344 [doi]
PST - ppublish
SO  - Autophagy. 2020 Oct;16(10):1918-1920. doi: 10.1080/15548627.2020.1797344. Epub 
      2020 Aug 10.