PMID- 32772900
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20240330
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 52
IP  - 8
DP  - 2020 Dec
TI  - Gut microbes in neurocognitive and mental health disorders.
PG  - 423-443
LID - 10.1080/07853890.2020.1808239 [doi]
AB  - INTRODUCTION: As individuals age, the prevalence of neurocognitive and mental 
      health disorders increases. Current biomedical treatments do not completely 
      address the management of these conditions. Despite new pharmacological therapy 
      the challenges of managing these diseases remain.There is increasing evidence 
      that the Gut Microbiome (GM) and microbial dysbiosis contribute to some of the 
      more prevalent mental health and neurocognitive disorders, such as depression, 
      anxiety, obsessive-compulsive disorder (OCD), post-traumatic stress disorder 
      (PTSD), schizophrenia, bipolar disorder (BP), and dementia as well as the 
      behavioural and psychological symptoms of dementia (BPSD) through the 
      microbiota-gut-brain axis. Methodology: Scoping review about the effect of gut 
      microbiota on neurocognitive and mental health disorders. RESULTS: This scoping 
      review found there is an evolving evidence of the involvement of the gut 
      microbiota in the pathophysiology of neurocognitive and mental health disorders. 
      This manuscript also discusses how the psychotropics used to treat these 
      conditions may have an antimicrobial effect on GM, and the potential for new 
      strategies of management with probiotics and faecal transplantation. CONCLUSIONS: 
      This understanding can open up the need for a gut related approach in these 
      disorders as well as unlock the door for the role of gut related microbiota 
      management. KEY MESSAGES Challenges of managing mental health conditions remain 
      in spite of new pharmacological therapy. Gut dysbiosis is seen in various mental 
      health conditions. Various psychotropic medications can have an influence on the 
      gut microbiota by their antimicrobial effect.
FAU - Halverson, Tyler
AU  - Halverson T
AD  - Department of Medicine, Division of Psychiatry, University of Alberta, Edmonton, 
      Alberta Canada.
FAU - Alagiakrishnan, Kannayiram
AU  - Alagiakrishnan K
AD  - Department of Medicine, Division of Geriatric Medicine, University of Alberta, 
      Edmonton, Alberta, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200831
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Cognition/drug effects/physiology
MH  - Combined Modality Therapy/methods
MH  - Dysbiosis/complications/microbiology/physiopathology/*therapy
MH  - *Fecal Microbiota Transplantation
MH  - Gastrointestinal Microbiome/drug effects/*physiology
MH  - Humans
MH  - Mental Disorders/microbiology/physiopathology/*therapy
MH  - Mental Health
MH  - Probiotics/*administration & dosage
MH  - Psychotropic Drugs/adverse effects
MH  - Treatment Outcome
PMC - PMC7877977
OTO - NOTNLM
OT  - Gut microbiota
OT  - antimicrobial activity
OT  - mental health
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2020/08/11 06:00
MHDA- 2021/07/27 06:00
PMCR- 2020/08/31
CRDT- 2020/08/11 06:00
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2020/08/11 06:00 [entrez]
PHST- 2020/08/31 00:00 [pmc-release]
AID - 1808239 [pii]
AID - 10.1080/07853890.2020.1808239 [doi]
PST - ppublish
SO  - Ann Med. 2020 Dec;52(8):423-443. doi: 10.1080/07853890.2020.1808239. Epub 2020 
      Aug 31.