PMID- 32774278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-680X (Print)
IS  - 1662-680X (Electronic)
IS  - 1662-680X (Linking)
VI  - 12
IP  - 2
DP  - 2020 May-Aug
TI  - Epstein-Barr Virus-Associated Encephalopathy Presenting with Nonconvulsive Status 
      Epilepticus in an Immunosuppressive State.
PG  - 214-221
LID - 10.1159/000507976 [doi]
AB  - Epstein-Barr virus (EBV) infection is occasionally accompanied by central nervous 
      system (CNS) complications, particularly in immunosuppressed patients. However, 
      the symptoms and clinical features of EBV infection in the CNS are rather 
      heterogeneous and remain unknown. We herein describe the first reported adult 
      case manifesting nonconvulsive status epilepticus (NCSE), possibly associated 
      with reactivation of EBV in an immunosuppressive state. A 63-year-old man with a 
      history of acute myeloid leukemia and taking immunosuppressants was admitted due 
      to progressively impaired consciousness without any focal neurological signs, 
      including paralysis or convulsions. Arterial spin labeling magnetic resonance 
      imaging (ASL-MRI) and brain perfusion single-photon emission computed tomography 
      showed hyperperfusion in the right temporal region, despite no morphological 
      abnormalities in other MRI sequences. White blood cell counts, EBV viral load, 
      and virus-capsid antigen IgG in cerebrospinal fluid were elevated. We diagnosed 
      him with EBV-associated encephalopathy presenting with NCSE. Administration of 
      levetiracetam, an antiepileptic, improved the consciousness and the abnormal 
      hyperperfusion. This case suggests a new concept of EBV-associated encephalopathy 
      leading to epilepsy, particularly in immunosuppressed patients.
CI  - Copyright (c) 2020 by S. Karger AG, Basel.
FAU - Ohya, Yuichiro
AU  - Ohya Y
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Nakamura, Kuniyuki
AU  - Nakamura K
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Wakisaka, Yoshinobu
AU  - Wakisaka Y
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Sato, Hiroaki
AU  - Sato H
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Wakisaka, Kayo
AU  - Wakisaka K
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Kumamoto, Masaya
AU  - Kumamoto M
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Muraya, Yohei
AU  - Muraya Y
AD  - Cerebrovascular and Neurology Center, National Hospital Organization 
      Fukuoka-Higashi Medical Center, Koga, Japan.
FAU - Kuroda, Junya
AU  - Kuroda J
AD  - Cerebrovascular and Neurology Center, National Hospital Organization 
      Fukuoka-Higashi Medical Center, Koga, Japan.
FAU - Nakane, Hiroshi
AU  - Nakane H
AD  - Cerebrovascular and Neurology Center, National Hospital Organization 
      Fukuoka-Higashi Medical Center, Koga, Japan.
FAU - Yoshimoto, Goichi
AU  - Yoshimoto G
AD  - Department of Medicine and Biosystemic Science, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka, Japan.
FAU - Kitazono, Takanari
AU  - Kitazono T
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
FAU - Ago, Tetsuro
AU  - Ago T
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Fukuoka, Japan.
LA  - eng
PT  - Case Reports
DEP - 20200622
PL  - Switzerland
TA  - Case Rep Neurol
JT  - Case reports in neurology
JID - 101517693
PMC - PMC7383209
OTO - NOTNLM
OT  - Encephalopathy
OT  - Epilepsy
OT  - Epstein-Barr virus
OT  - Hyperperfusion
OT  - Nonconvulsive status epilepticus
COIS- The authors have no conflicts of interest to declare.
EDAT- 2020/08/11 06:00
MHDA- 2020/08/11 06:01
PMCR- 2020/06/22
CRDT- 2020/08/11 06:00
PHST- 2020/03/26 00:00 [received]
PHST- 2020/04/16 00:00 [accepted]
PHST- 2020/08/11 06:00 [entrez]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2020/08/11 06:01 [medline]
PHST- 2020/06/22 00:00 [pmc-release]
AID - crn-0012-0214 [pii]
AID - 10.1159/000507976 [doi]
PST - epublish
SO  - Case Rep Neurol. 2020 Jun 22;12(2):214-221. doi: 10.1159/000507976. eCollection 
      2020 May-Aug.