PMID- 32774753
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 12
IP  - 7
DP  - 2020
TI  - Cytokine and chemokine profile changes in patients after intravitreal conbercept 
      injection for center macular edema due to branch retinal vein occlusion.
PG  - 4001-4008
AB  - PURPOSE: This study aimed to ascertain cytokine concentrations in patients with 
      center macular edema (CME) due to branch retinal vein occlusion (BRVO) before and 
      during the period of treatment with intravitreal injection of conbercept (IVC) 
      and to determine the relationship between these concentrations and disease 
      activity. MATERIALS AND METHODS: The Bio-Plex((R)) 200 System and the Bio-Plex(TM) 
      Human Cytokine Standard 27-Plex, Group I (Bio-Rad, Hercules, California, USA) 
      were used to detect cytokine concentrations in aqueous humour. Experimental 
      aqueous humour samples were collected from 22 patients with CME due to BRVO when 
      IVC was administered at baseline and at 1 month, and control aqueous samples were 
      collected by limbal paracentesis from 16 patients undergoing routine cataract 
      surgery. RESULTS: Significantly higher concentrations of vascular endothelial 
      growth factor (VEGF), interleukin 6 (IL-6), IL-8, interferon gamma-induced 
      protein 10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1) were found in 
      the BRVO group than in the control group. In the BRVO group, VEGF levels were 
      significantly lower one month after IVC than at baseline. However, the other 
      cytokines did not significantly change during IVC treatment. The decreases in 
      VEGF levels were closely related to the decreases in central macular thickness 
      (CMT) and the increases in best-corrected visual acuity (BCVA). CONCLUSIONS: Many 
      factors, such as angiogenic, inflammatory and growth factors, contribute to the 
      pathogenesis of CME due to BRVO. IVC had no significant effect on cytokines other 
      than VEGF in patients with CME due to BRVO. The changes in BCVA and CMT were 
      associated with VEGF levels after IVC treatment.
CI  - AJTR Copyright (c) 2020.
FAU - Wei, Qingquan
AU  - Wei Q
AD  - Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University 
      Shanghai 200072, P. R. China.
FAU - Sun, Tingting
AU  - Sun T
AD  - Department of Ophthalmology, Shanxi Medical University Taiyuan 030001, Shanxi 
      Province, P. R. China.
FAU - Wan, Zhongqi
AU  - Wan Z
AD  - School of Public Health, Nanjing Medical University Nanjing 211166, Jiangsu 
      Province, P. R. China.
FAU - Zhang, Yongjie
AU  - Zhang Y
AD  - Department of Human Anatomy, Nanjing Medical University Nanjing 211166, Jiangsu 
      Province, P. R. China.
FAU - Peng, Qing
AU  - Peng Q
AD  - Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University 
      Shanghai 200072, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20200715
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC7407675
OTO - NOTNLM
OT  - Branch retinal vein occlusion
OT  - conbercept
OT  - intraocular cytokines
OT  - intravitreal implant
COIS- None.
EDAT- 2020/08/11 06:00
MHDA- 2020/08/11 06:01
PMCR- 2020/07/15
CRDT- 2020/08/11 06:00
PHST- 2020/01/29 00:00 [received]
PHST- 2020/05/31 00:00 [accepted]
PHST- 2020/08/11 06:00 [entrez]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2020/08/11 06:01 [medline]
PHST- 2020/07/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2020 Jul 15;12(7):4001-4008. eCollection 2020.