PMID- 32774805
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 23
IP  - 7
DP  - 2020 Jul
TI  - Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association 
      with prognostic factors.
PG  - 853-857
LID - 10.22038/ijbms.2020.41468.9804 [doi]
AB  - OBJECTIVES: To validate certain markers for cancer stem cell populations and 
      their clinical importance in Wilms tumor (WT). MATERIALS AND METHODS: 
      Immunohistochemical study for CD133 and CD56/NCAM was performed on forty-six 
      cases of WT that were diagnosed between 1999 and 2015, and the association of 
      these markers with survival and prognostic factors was analyzed. RESULTS: 
      Thirty-four (73.9%) of WTs were positive for CD133 and thirty-nine (84.8%) were 
      positive for CD56/NCAM. A significant positive correlation between CD133 and 
      CD56/NCAM expression and the National Wilms Tumor Stage (NWTS) and death was 
      found. Moreover, overall survival time was significantly correlated with CD133 
      and CD56/NCAM H-score, NWTS stage, and death. CONCLUSION: It seems that CD133 and 
      CD56/NCAM expressions can be used as strong prognostic parameters for the 
      survival of patients with WT and can be used to predict WT patients' stage. 
      Moreover, their targeted therapies can abolish cancer stem cells in children with 
      recurrent tumors.
FAU - Jafarian, Amir Hossein
AU  - Jafarian AH
AD  - Department of Pathology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Zabolinejad, Nona
AU  - Zabolinejad N
AD  - Department of Pathology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mohamadian Roshan, Nema
AU  - Mohamadian Roshan N
AD  - Department of Pathology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Hashemi, Sara
AU  - Hashemi S
AD  - Department of Pathology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Gharib, Masoumeh
AU  - Gharib M
AD  - Department of Pathology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC7395190
OTO - NOTNLM
OT  - CD133
OT  - Immunohistochemistry
OT  - Neural cell adhesion - molecules
OT  - Stem cells
OT  - Wilms tumor
EDAT- 2020/08/11 06:00
MHDA- 2020/08/11 06:01
PMCR- 2020/07/01
CRDT- 2020/08/11 06:00
PHST- 2020/08/11 06:00 [entrez]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2020/08/11 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.22038/ijbms.2020.41468.9804 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2020 Jul;23(7):853-857. doi: 
      10.22038/ijbms.2020.41468.9804.