PMID- 32775423
OWN - NLM
STAT- MEDLINE
DCOM- 20210422
LR  - 20240329
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic 
      Aneurysms in Chinese Population.
PG  - 4691026
LID - 10.1155/2020/4691026 [doi]
LID - 4691026
AB  - OBJECTIVE: To shed light on the association between hyperhomocysteinemia (HHcy) 
      and thoracoabdominal aortic aneurysms (TAAAs). METHODS: From July 2013 to March 
      2017, we conducted a matched case-control study involving individuals who 
      presented to the Chinese People's Liberation Army General Hospital and underwent 
      thoracoabdominal magnetic resonance angiography or computed tomography 
      angiography. A total of 73 patients with TAAAs were enrolled in the case group, 
      and 219 sex-matched subjects without TAAAs were included in the control group. We 
      then examined the relationship between HHcy and TAAAs by logistic regression 
      models and subgroup as well as interaction analyses. RESULTS: Serum total 
      homocysteine (tHcy) concentrations and the proportion of HHcy were significantly 
      higher in the patients with TAAAs than in those without TAAAs (P < 0.001). 
      Furthermore, the multivariate logistic regression models indicated that 
      participants with HHcy had a 2.14-fold higher risk of TAAAs than those with a 
      normal serum tHcy level (adjusted odds ratio (OR), 2.14; 95% confidence interval, 
      1.00-4.56). Similarly, each 1 mumol/L increase in the serum tHcy concentration was 
      associated with a 4% higher risk of TAAAs (adjusted OR, 1.04; 95% confidence 
      interval, 1.00-1.07). Subgroup analyses indicated that HHcy tended to be 
      associated with a greater risk of TAAAs in all stratified subgroups (adjusted ORs 
      > 1). Furthermore, the interaction analyses revealed no interactive role in the 
      association between HHcy and TAAAs. CONCLUSIONS: The present case-control study 
      suggests that HHcy is an independent risk factor for TAAAs. Larger prospective 
      cohort studies are warranted to validate these findings.
CI  - Copyright (c) 2020 Jianqing Deng et al.
FAU - Deng, Jianqing
AU  - Deng J
AUID- ORCID: 0000-0001-7319-0288
AD  - Department of Vascular and Endovascular Surgery, The First Medical Centre, 
      Chinese PLA General Hospital, Beijing, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Vascular and Endovascular Surgery, The First Medical Centre, 
      Chinese PLA General Hospital, Beijing, China.
FAU - Cao, Long
AU  - Cao L
AD  - Department of Vascular and Endovascular Surgery, The First Medical Centre, 
      Chinese PLA General Hospital, Beijing, China.
AD  - Department of General Surgery, Chinese PLA No.983 Hospital, Tianjin, China.
FAU - Wang, Qun
AU  - Wang Q
AD  - Department of Neurosurgery, The First Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Zhang, Hongpeng
AU  - Zhang H
AD  - Department of Vascular and Endovascular Surgery, The First Medical Centre, 
      Chinese PLA General Hospital, Beijing, China.
FAU - Liu, Xiaoping
AU  - Liu X
AD  - Department of Vascular and Endovascular Surgery, The First Medical Centre, 
      Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Wei
AU  - Guo W
AUID- ORCID: 0000-0001-6212-8390
AD  - Department of Vascular and Endovascular Surgery, The First Medical Centre, 
      Chinese PLA General Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20200728
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aortic Aneurysm, Thoracic/blood/*etiology
MH  - Asian People
MH  - Case-Control Studies
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Risk Factors
PMC - PMC7407013
COIS- The authors have no competing interests.
EDAT- 2020/08/11 06:00
MHDA- 2021/04/23 06:00
PMCR- 2020/07/28
CRDT- 2020/08/11 06:00
PHST- 2020/06/08 00:00 [received]
PHST- 2020/07/02 00:00 [accepted]
PHST- 2020/08/11 06:00 [entrez]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2021/04/23 06:00 [medline]
PHST- 2020/07/28 00:00 [pmc-release]
AID - 10.1155/2020/4691026 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Jul 28;2020:4691026. doi: 10.1155/2020/4691026. eCollection 
      2020.