PMID- 32775463 OWN - NLM STAT- MEDLINE DCOM- 20210702 LR - 20220416 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2020 DP - 2020 TI - Sex-Specific Association of Serum Uric Acid Level and Change in Hyperuricemia Status with Risk of Type 2 Diabetes Mellitus: A Large Cohort Study in China. PG - 9637365 LID - 10.1155/2020/9637365 [doi] LID - 9637365 AB - BACKGROUND: Conflicting findings have been reported regarding the sex-specific association between serum uric acid (SUA) level and type 2 diabetes mellitus (T2DM) risk, and no study has explored the association between the change in hyperuricemia status and T2DM risk. The study was aimed at exploring the sex-specific association of baseline SUA and changes in hyperuricemia status with T2DM risk. METHODS: We included 37,296 eligible adults without T2DM at the first examination who attended the baseline examination and at least one follow-up annual examination. Cox and logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) for T2DM risk associated with baseline SUA and the change in hyperuricemia status, respectively. RESULTS: During a median follow-up of 3.09 years, of 37,296 eligible adults, 2,263 developed T2DM. Compared with the first SUA quartile, higher quartiles were associated with an increased risk of T2DM in women (HR 1.78, 95% CI 1.17-2.71 for Q3 and 1.93, 1.27-2.93 for Q4; P (trend) < 0.001) but not in men. Compared with women with a persistent normal SUA level at baseline and the last follow-up, T2DM risk increased significantly among those whose SUA status changed from normal at baseline to hyperuricemia at the last follow-up (OR 1.71, 95% CI 1.12-2.55) and those with persistent hyperuricemia at baseline and the last follow-up (OR 2.37, 95% CI 1.60-3.46). However, for men, a nonsignificant association was found between the change in hyperuricemia status and T2DM risk. CONCLUSIONS: Baseline SUA and the change in hyperuricemia status were associated with T2DM risk only among women. The findings suggest the importance of monitoring SUA levels and maintaining them within a normal range for preventing or reducing incident T2DM in Chinese women. CI - Copyright (c) 2020 Yanmei Lou et al. FAU - Lou, Yanmei AU - Lou Y AUID- ORCID: 0000-0002-5107-5331 AD - Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, China. FAU - Qin, Pei AU - Qin P AUID- ORCID: 0000-0003-2303-0379 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, China. FAU - Wang, Changyi AU - Wang C AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Ma, Jianping AU - Ma J AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Peng, Xiaolin AU - Peng X AUID- ORCID: 0000-0002-0958-7042 AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Xu, Shan AU - Xu S AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Chen, Hongen AU - Chen H AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Zhao, Dan AU - Zhao D AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Wang, Li AU - Wang L AD - Department of Non-Communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, China. FAU - Liu, Dechen AU - Liu D AUID- ORCID: 0000-0002-4136-4148 AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, China. FAU - Li, Yang AU - Li Y AUID- ORCID: 0000-0003-1495-5230 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, China. FAU - Zhao, Ping AU - Zhao P AD - Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, China. FAU - Han, Dezhu AU - Han D AD - Beijing Fangshan District Yanshan Commission of Culture, Health and Family Planning, Beijing, China. FAU - Hu, Dongsheng AU - Hu D AUID- ORCID: 0000-0002-9998-8041 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, China. AD - Department of Epidemiology and Health Statistics, School of Public Health, Zhengzhou University, Zhengzhou, Henan, China. FAU - Hu, Fulan AU - Hu F AUID- ORCID: 0000-0002-2386-1503 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, China. LA - eng PT - Journal Article DEP - 20200723 PL - England TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 RN - 268B43MJ25 (Uric Acid) SB - IM MH - Adult MH - China/epidemiology MH - Cohort Studies MH - Diabetes Mellitus, Type 2/blood/epidemiology/*etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Hyperuricemia/blood/*complications/epidemiology MH - Male MH - Middle Aged MH - Proportional Hazards Models MH - Risk Factors MH - Sex Factors MH - Uric Acid/*blood MH - Young Adult PMC - PMC7396085 COIS- The authors declare that they have no conflicts of interest. EDAT- 2020/08/11 06:00 MHDA- 2021/07/03 06:00 PMCR- 2020/07/23 CRDT- 2020/08/11 06:00 PHST- 2020/02/18 00:00 [received] PHST- 2020/05/30 00:00 [revised] PHST- 2020/06/29 00:00 [accepted] PHST- 2020/08/11 06:00 [entrez] PHST- 2020/08/11 06:00 [pubmed] PHST- 2021/07/03 06:00 [medline] PHST- 2020/07/23 00:00 [pmc-release] AID - 10.1155/2020/9637365 [doi] PST - epublish SO - J Diabetes Res. 2020 Jul 23;2020:9637365. doi: 10.1155/2020/9637365. eCollection 2020.