PMID- 32776394
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1365-2869 (Electronic)
IS  - 0962-1105 (Linking)
VI  - 30
IP  - 3
DP  - 2021 Jun
TI  - Altered cardiac repolarisation in highlanders with high-altitude pulmonary 
      hypertension during wakefulness and sleep.
PG  - e13153
LID - 10.1111/jsr.13153 [doi]
AB  - High-altitude pulmonary hypertension (HAPH) is an altitude-related illness 
      associated with hypoxaemia that may promote sympathetic excitation and 
      prolongation of the QT interval. The present case-control study tests whether QT 
      intervals, markers of malignant cardiac arrhythmias, are prolonged in highlanders 
      with HAPH (HAPH+) compared to healthy highlanders (HH) and healthy lowlanders 
      (LL). The mean pulmonary artery pressure (mPAP) was measured by echocardiography 
      in 18 HAPH+ (mPAP, 34 mmHg) and 18 HH (mPAP, 23 mmHg) at 3,250 m, and 18 LL 
      (mPAP, 18 mmHg) at 760 m, Kyrgyzstan (p < .05 all mPAP comparisons). Groups were 
      matched for age, sex and body mass index. Electrocardiography and pulse oximetry 
      were continuously recorded during nocturnal polysomnography. The heart 
      rate-adjusted QT interval, QTc, was averaged over consecutive 1-min periods. 
      Overall, a total of 26,855 averaged 1-min beat-by-beat periods were 
      semi-automatically analysed. In HAPH+, maximum nocturnal QTc was longer during 
      sleep (median 456 ms) than wakefulness (432 ms, p < .05) and exceeded 
      corresponding values in HH (437 and 419 ms) and LL (430 and 406 ms), p < .05, 
      respectively. The duration of night-time QTc >440 ms was longer in HAPH+ (median 
      144 min) than HH and LL (46 and 14 min, p < .05, respectively). HAPH+ had higher 
      night-time heart rate (median 78 beats/min) than HH and LL (66 and 65 beats/min, 
      p < .05, respectively), lower mean nocturnal oxygen saturation than LL (88% 
      versus 95%, p < .05) and more cyclic oxygen desaturations (median 24/hr) than HH 
      and LL (13 and 3/hr, p < .05, respectively). In conclusion, HAPH was associated 
      with higher night-time heart rate, hypoxaemia and longer QTc versus HH and LL, 
      and may represent a substrate for increased risk of malignant cardiac 
      arrhythmias.
CI  - (c) 2020 European Sleep Research Society.
FAU - Aeschbacher, Sayaka S
AU  - Aeschbacher SS
AUID- ORCID: 0000-0003-2815-1639
AD  - Department of Respiratory Medicine, Sleep Disorders Center, University Hospital 
      of Zurich, Zurich, Switzerland.
FAU - Latshang, Tsogyal D
AU  - Latshang TD
AD  - Department of Respiratory Medicine, Sleep Disorders Center, University Hospital 
      of Zurich, Zurich, Switzerland.
FAU - Sheraliev, Ulan
AU  - Sheraliev U
AD  - Department of Respiratory Medicine, National Center for Cardiology and Internal 
      Medicine, Bishkek, Kyrgyzstan.
FAU - Marazhapov, Nuriddin H
AU  - Marazhapov NH
AD  - Department of Respiratory Medicine, National Center for Cardiology and Internal 
      Medicine, Bishkek, Kyrgyzstan.
FAU - Ulrich, Silvia
AU  - Ulrich S
AD  - Department of Respiratory Medicine, Sleep Disorders Center, University Hospital 
      of Zurich, Zurich, Switzerland.
FAU - Sooronbaev, Talant M
AU  - Sooronbaev TM
AUID- ORCID: 0000-0002-5609-0944
AD  - Department of Respiratory Medicine, National Center for Cardiology and Internal 
      Medicine, Bishkek, Kyrgyzstan.
FAU - Bloch, Konrad E
AU  - Bloch KE
AUID- ORCID: 0000-0002-2377-7387
AD  - Department of Respiratory Medicine, Sleep Disorders Center, University Hospital 
      of Zurich, Zurich, Switzerland.
FAU - Furian, Michael
AU  - Furian M
AUID- ORCID: 0000-0002-8518-5029
AD  - Department of Respiratory Medicine, Sleep Disorders Center, University Hospital 
      of Zurich, Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200809
PL  - England
TA  - J Sleep Res
JT  - Journal of sleep research
JID - 9214441
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Altitude Sickness/*complications/physiopathology
MH  - Case-Control Studies
MH  - Electrocardiography/*methods
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/complications/*etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sleep/*physiology
MH  - Wakefulness/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - QTc prolongation
OT  - high-altitude illness
OT  - high-altitude pulmonary hypertension
OT  - hypoxaemia
EDAT- 2020/08/11 06:00
MHDA- 2021/07/16 06:00
CRDT- 2020/08/11 06:00
PHST- 2020/07/03 00:00 [revised]
PHST- 2020/05/27 00:00 [received]
PHST- 2020/07/06 00:00 [accepted]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2020/08/11 06:00 [entrez]
AID - 10.1111/jsr.13153 [doi]
PST - ppublish
SO  - J Sleep Res. 2021 Jun;30(3):e13153. doi: 10.1111/jsr.13153. Epub 2020 Aug 9.