PMID- 32776754
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 66
IP  - 8
DP  - 2020 Aug 1
TI  - PvuII and XbaI in Estrogen Receptor 1 (ESR1) Polymorphisms and Susceptibility to 
      Endometriosis Risk.
LID - 10.7754/Clin.Lab.2020.191209 [doi]
AB  - BACKGROUND: Studies have shown that variants in PvuII and XbaI loci are 
      associated with the occurrence and progression of endometriosis (EM), while the 
      results were in great debate. METHODS: A systematic review and meta-analysis were 
      conducted to evaluate the role of PvuII and XbaI polymor-phisms in estrogen 
      receptors (ESR1). The primary sources of the reviewed studies through December 
      2018, with restriction on the language of English and Chinese, were Pubmed and 
      Embase and CNKI. The pooled odds ratio 95% confidence intervals (CIs) were 
      calculated to evaluate the associations of Pvull and Xbal polymorphisms with the 
      risk of EM by using the STATA 14.0 software. RESULTS: A total of 18 studies with 
      4,975 patients, 2,222 in the case group, 2,753 in the control group, were in the 
      final analysis. Overall pooled outcomes did not indicate significant correlations 
      between the ESR1 Pvull/Xbal polymorphisms and the EM development. In subgroup 
      analysis, PvuII was associated with endometriosis only for stage I - III and only 
      under a recessive model (OR = 1.61, 95% CI: 1.03 to 2.07; p = 0.03). Xbal was 
      associated with endometriosis only for the non-PCR-RFLP genotype method and also 
      only under a recessive model (OR = 2.10, 95% CI: 1.21 to 4.47; p = 0.04). 
      CONCLUSIONS: This present meta-analysis reported that polymorphisms of PvuII or 
      Xbal were not related to the susceptibility to EM except for a slight association 
      of stage I-III endometriosis and non-PCR-RFLP under recessive model. Future, 
      well-designed large studies are eagerly awaited to confirm our conclusions.
FAU - Wang, Jingwen
AU  - Wang J
FAU - Hu, Rong
AU  - Hu R
FAU - Wang, Jingjing
AU  - Wang J
FAU - He, Qian
AU  - He Q
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Case-Control Studies
MH  - *Endometriosis/genetics
MH  - *Estrogen Receptor alpha/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
EDAT- 2020/08/11 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/11 06:00
PHST- 2020/08/11 06:00 [entrez]
PHST- 2020/08/11 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
AID - 10.7754/Clin.Lab.2020.191209 [doi]
PST - ppublish
SO  - Clin Lab. 2020 Aug 1;66(8). doi: 10.7754/Clin.Lab.2020.191209.