PMID- 32777920
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 17
IP  - 8
DP  - 2020 Aug
TI  - MRI-Based Multimodal Approach to the Assessment of Clinical Symptom Severity of 
      Obsessive-Compulsive Disorder.
PG  - 777-785
LID - 10.30773/pi.2020.0124 [doi]
AB  - OBJECTIVE: This study assessed the associations of the abnormal brain activation 
      and functional connectivity (FC) during memory processing and brain volume 
      alteration in conjunction with psychiatric symptom severity in patients with 
      obsessive-compulsive disorder (OCD). METHODS: Twenty-OCD patients and 20-healthy 
      controls (HC) underwent T1-weighted and functional imaging underlying explicit 
      memory task. RESULTS: In memory encoding, OCD patients showed higher activities 
      in right/left (Rt./Lt.) inferior temporal gyrus (ITG), medial prefrontal cortex 
      (MPFC), dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex 
      (ACC), compared with HC. In task-based FC, caudate (Cd) was positively connected 
      with DLPFC and ITG in OCD, while HC showed different connectivities of Cd-ACC and 
      Rt.-Lt. ITG. In memory retrieval, only Cd was activated in OCD patients. Cd was 
      positively connected with DLPFC and vmPFC in OCD, but negatively connected 
      between same brain areas in HC. OCD patients showed increased gray matter (GM) 
      volumes of cerebellum, DLPFC, orbitofrontal cortex (OFC), hippocampus, Cd and 
      ITG, and concurrently, increased white matter volumes of DLPFC. In OCD patients, 
      GM volumes of Cd and OFC were positively correlated with HAMA and Y-BOCS. 
      Functional activity changes of Cd in OCD were positively correlated with Y-BOCS. 
      CONCLUSION: Our findings support to accessing clinical symptom and its severity 
      linked by brain structural deformation and functional abnormality in OCD 
      patients.
FAU - Park, Shin-Eui
AU  - Park SE
AD  - Center for Research Equipment, Korea Basic Science Institute, Cheongju, Republic 
      of Korea.
FAU - Kim, Byeong-Chae
AU  - Kim BC
AD  - Department of Neurology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Yang, Jong-Chul
AU  - Yang JC
AD  - Department of Psychiatry, Research Institute of Clinical Medicine of Jeonbuk 
      National University, Jeonju, Republic of Korea.
FAU - Jeong, Gwang-Woo
AU  - Jeong GW
AD  - Department of Radiology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
LA  - eng
GR  - 2018R1A2B2006260/National Research Foundation of Korea/
GR  - Ministry of Science and ICT/
GR  - 2017-2022/Chonnam National University/
GR  - Jeonbuk National University Hospital/
PT  - Journal Article
DEP - 20200812
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC7449838
OTO - NOTNLM
OT  - Explicit memory
OT  - Functional connectivity
OT  - Functional magnetic resonance imaging
OT  - Obsessive-compulsive disorder
OT  - Voxel-based morphometry
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2020/08/12 06:00
MHDA- 2020/08/12 06:01
PMCR- 2020/08/01
CRDT- 2020/08/12 06:00
PHST- 2020/04/06 00:00 [received]
PHST- 2020/05/31 00:00 [accepted]
PHST- 2020/08/12 06:00 [pubmed]
PHST- 2020/08/12 06:01 [medline]
PHST- 2020/08/12 06:00 [entrez]
PHST- 2020/08/01 00:00 [pmc-release]
AID - pi.2020.0124 [pii]
AID - pi-2020-0124 [pii]
AID - 10.30773/pi.2020.0124 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2020 Aug;17(8):777-785. doi: 10.30773/pi.2020.0124. Epub 
      2020 Aug 12.