PMID- 32778100
OWN - NLM
STAT- MEDLINE
DCOM- 20210601
LR  - 20210601
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Aug 10
TI  - Study of hospitalization and mortality in Korean diabetic patients using the 
      diabetes complications severity index.
PG  - 122
LID - 10.1186/s12902-020-00605-5 [doi]
LID - 122
AB  - BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) is expected to 
      increase from 7.7% in 2017 to 8.4% in 2045 worldwide. Diabetes complications 
      contribute to morbidity and mortality. To evaluate whether the diabetes 
      complications severity index (DCSI) was associated with increased risks of 
      mortality and hospitalization. METHODS: A retrospective cohort study was 
      conducted using the National Health Insurance Database (NHID) sample cohort of 
      1,102,047 patients (2002-2015) in Korea. Diabetes complications were evaluated at 
      2 years after the initial diagnosis and during the subsequent follow-up period 
      (mean duration 6.56 +/- 2.81 years). The type and severity of complications were 
      evaluated on the basis of the International Classification of Disease Ninth 
      (ICD-9) codes used in DCSI with 7 categories and 55 subcategories of 
      complications. The Cox proportional hazard and Poisson regression models were 
      used to evaluate the mortality and hospitalization rates. The incidence and 
      relative risk of diabetes complications as well as the risk of mortality and 
      hospitalization were the main outcome measures. RESULTS: A total of 27,871 
      patients were finally included and grouped by the number of complications present 
      at 2 years. Four hundred ninety patients (5.37%) died without complications, 659 
      (7.31%) died with one complication and 1153 (11.85%) died with two or more 
      complications. As DCSI at index date increased, the risk of additional new 
      diabetes complications increased by 26% [relative risk (RR) 1.26, 95% CI 
      1.25-1.27]. The risks of mortality and hospitalization were linearly related to 
      DCSI [hazard ratio 1.13 (95% CI 1.11-1.16), relative risk 1.04 (95% CI 
      1.03-1.06)]. CONCLUSIONS: Patients with higher incidence and severity of diabetes 
      complications have increased risks of mortality and hospitalization.
FAU - Yoo, Hyunju
AU  - Yoo H
AD  - Division of Clinical Pharmacy, College of Pharmacy, Ajou University, 206 
      Worldcup-ro Yeongtong-gu, Suwon, 16499, South Korea.
FAU - Choo, Eunjung
AU  - Choo E
AD  - Division of Clinical Pharmacy, College of Pharmacy, Ajou University, 206 
      Worldcup-ro Yeongtong-gu, Suwon, 16499, South Korea.
FAU - Lee, Sukhyang
AU  - Lee S
AUID- ORCID: 0000-0002-8830-4353
AD  - Division of Clinical Pharmacy, College of Pharmacy, Ajou University, 206 
      Worldcup-ro Yeongtong-gu, Suwon, 16499, South Korea. suklee@ajou.ac.kr.
LA  - eng
GR  - S2019G000100302/Ajou University/
PT  - Journal Article
DEP - 20200810
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Aged
MH  - Cause of Death
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Diabetes Complications/*epidemiology/mortality/pathology
MH  - Diabetes Mellitus, Type 2/*epidemiology/mortality/pathology
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC7418200
OTO - NOTNLM
OT  - Diabetes complications
OT  - Diabetes mellitus
OT  - Korea
OT  - National Health Insurance Database
COIS- The authors declare that they have no competing interests.
EDAT- 2020/08/12 06:00
MHDA- 2021/06/02 06:00
PMCR- 2020/08/10
CRDT- 2020/08/12 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/07/31 00:00 [accepted]
PHST- 2020/08/12 06:00 [entrez]
PHST- 2020/08/12 06:00 [pubmed]
PHST- 2021/06/02 06:00 [medline]
PHST- 2020/08/10 00:00 [pmc-release]
AID - 10.1186/s12902-020-00605-5 [pii]
AID - 605 [pii]
AID - 10.1186/s12902-020-00605-5 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2020 Aug 10;20(1):122. doi: 10.1186/s12902-020-00605-5.