PMID- 32779510
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1724-6040 (Electronic)
IS  - 0391-3988 (Linking)
VI  - 44
IP  - 3
DP  - 2021 Mar
TI  - Lung ultrasound score as an indicator of dynamic lung compliance during 
      veno-venous extra-corporeal membrane oxygenation.
PG  - 194-198
LID - 10.1177/0391398820948870 [doi]
AB  - Decisions on weaning from veno-venous extra-corporeal membrane oxygenation 
      (VV-ECMO) requires the ability to maintain adequate gas exchange and work of 
      breathing with reductions in ECMO pump flow and fresh gas flow. Testing of the 
      readiness to wean the patient from ECMO however may vary dependent upon local 
      protocols and clinical judgment. This study sought to validate the use of the 
      LUS-score during VV-ECMO against the changes in chest x-ray infiltrates, dynamic 
      lung compliance (CLdyn) and VV-ECMO settings (as standard measures of native lung 
      function and the level of ECMO support) during the ECMO cycle. This prospective 
      cohort study of 10 patients on VV-ECMO compared the LUS score (range 0-36) within 
      48-h, day 5 and day 10 of commencement of ECMO (or on the day of ECMO 
      decannulation) to dynamic lung compliance, Murray Lung Injury Score and ECMO 
      settings. Seven Male and three Female patients were included (average age 
      37 years (SD 14.8) and weight 71 Kg (SD 16.9). Median (IQR) duration of ECMO, ICU 
      and hospital length of stay was 7.5 days (5.2-19.0), 12.5 days (8.5-22.7), 
      19.0 days (12.1- 36.1), respectively. There was a strong negative association 
      between LUS-score and dynamic lung compliance (r(s)(33) = -0.66, p < .001) 
      providing some validation on the use of the LUS score as a potential surrogate 
      measure of lung aeration and lung mechanics during VV-ECMO weaning.
FAU - Ntoumenopoulos, George
AU  - Ntoumenopoulos G
AUID- ORCID: 0000-0002-1088-3009
AD  - Department of Physiotherapy, St Vincent's Hospital, Australia.
FAU - Buscher, Hergen
AU  - Buscher H
AD  - Department of Intensive Care Medicine, St Vincent's Hospital, Australia.
AD  - Centre of Applied Medical Research, University of New South Wales, Australia.
FAU - Scott, Sean
AU  - Scott S
AD  - Department of Intensive Care Medicine, St Vincent's Hospital, Australia.
AD  - The University of Notre Dame, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200811
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
SB  - IM
MH  - Adult
MH  - Extracorporeal Membrane Oxygenation/methods
MH  - Female
MH  - Humans
MH  - Lung/diagnostic imaging/physiopathology
MH  - Lung Compliance/*physiology
MH  - Male
MH  - Prospective Studies
MH  - Pulmonary Gas Exchange
MH  - Reproducibility of Results
MH  - *Respiratory Distress Syndrome/physiopathology/therapy
MH  - Ultrasonography/*methods
MH  - Withholding Treatment/standards/statistics & numerical data
OTO - NOTNLM
OT  - ECMO
OT  - Ultrasound
OT  - lung compliance
OT  - oxygenation
EDAT- 2020/08/12 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/12 06:00
PHST- 2020/08/12 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/12 06:00 [entrez]
AID - 10.1177/0391398820948870 [doi]
PST - ppublish
SO  - Int J Artif Organs. 2021 Mar;44(3):194-198. doi: 10.1177/0391398820948870. Epub 
      2020 Aug 11.