PMID- 32780655
OWN - NLM
STAT- MEDLINE
DCOM- 20210224
LR  - 20210224
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 30
IP  - 10
DP  - 2020 Oct
TI  - Anatomic Laparoscopic Liver Resection in the Scenario of the Hepatocellular 
      Carcinoma: A Systematic Review and Meta-Analysis.
PG  - 1076-1081
LID - 10.1089/lap.2020.0562 [doi]
AB  - Aim: To assess the impact of the laparoscopic anatomic resections (LARs) on 
      hepatocellular carcinoma (HCC) patients, analyzing the pooled short- and 
      long-term outcomes of this technique and comparing it with the standard open 
      approach [open anatomic resections (OAR)]. Material and Methods: A systematic 
      literature search was performed in PubMed, Embase, and Scopus for studies 
      published between 2010 and 2020 concerning LAR for HCC. Results: After screening 
      311 articles, 10 studies with a total of 398 patients who underwent LAR for HCC 
      were included. The pooled cohort included mostly male (76.6%), Child A (98.2%), 
      with hepatitis B virus (HBV)-related disease (60.5%). The pooled conversion rate 
      was 7.3%. The pooled overall complication rate was 10.2 with a mortality rate of 
      1.0%. In the pooled analyses of only comparative studies, LAR group included 378 
      versus 455 in OAR. Operative time was longer in the LAR group (329 minutes versus 
      248; P = .001). Blood loss (179 versus 331 mL; P = .018) was lower in the LAR 
      group. The pooled mean length of hospital stay was 8.4 days in LARs and 11.3 in 
      OARs (P = .002). The pooled rate of postoperative complications was higher in the 
      OAR group (25.3 versus 13.8; P = .009), while mortality rates were similar. The 
      LAR group had a pooled 3- and 5-year overall survival of 90.1 and 81.9 versus 
      83.5 and 80.7 of the OARs (P > .05), respectively. Conclusions: In conclusion, 
      the LAR for HCC is safe and associated with decreased blood loss and length of 
      hospital stay. Survival rates are comparable with those of the conventional open 
      approach.
FAU - Solaini, Leonardo
AU  - Solaini L
AD  - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 
      Bologna, Italy.
AD  - General and Oncologic Surgery, Morgagni-Pierantoni Hospital, AUSL Romagna, Forli, 
      Italy.
FAU - Bocchino, Antonio
AU  - Bocchino A
AD  - General and Oncologic Surgery, Morgagni-Pierantoni Hospital, AUSL Romagna, Forli, 
      Italy.
AD  - Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of 
      Modena, Modena, Italy.
FAU - Cucchetti, Alessandro
AU  - Cucchetti A
AD  - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 
      Bologna, Italy.
AD  - General and Oncologic Surgery, Morgagni-Pierantoni Hospital, AUSL Romagna, Forli, 
      Italy.
FAU - Ercolani, Giorgio
AU  - Ercolani G
AD  - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 
      Bologna, Italy.
AD  - General and Oncologic Surgery, Morgagni-Pierantoni Hospital, AUSL Romagna, Forli, 
      Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200811
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Blood Loss, Surgical
MH  - Carcinoma, Hepatocellular/*surgery
MH  - Conversion to Open Surgery
MH  - Hepatectomy/adverse effects/*methods
MH  - Humans
MH  - *Laparoscopy/adverse effects
MH  - Length of Stay
MH  - Liver Neoplasms/*surgery
MH  - Operative Time
MH  - Postoperative Complications/etiology
MH  - Survival Rate
MH  - Treatment Outcome
OTO - NOTNLM
OT  - anatomic resections
OT  - hepatocellular carcinoma
OT  - laparoscopy
OT  - meta-analysis
OT  - minimally invasive surgery
OT  - survival
EDAT- 2020/08/12 06:00
MHDA- 2021/02/25 06:00
CRDT- 2020/08/12 06:00
PHST- 2020/08/12 06:00 [pubmed]
PHST- 2021/02/25 06:00 [medline]
PHST- 2020/08/12 06:00 [entrez]
AID - 10.1089/lap.2020.0562 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2020 Oct;30(10):1076-1081. doi: 
      10.1089/lap.2020.0562. Epub 2020 Aug 11.