PMID- 32780780
OWN - NLM
STAT- MEDLINE
DCOM- 20201014
LR  - 20201014
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 8
DP  - 2020
TI  - Biventricular myocardial adaptation in patients with repaired tetralogy of 
      Fallot: Mechanistic insights from magnetic resonance imaging tissue phase 
      mapping.
PG  - e0237193
LID - 10.1371/journal.pone.0237193 [doi]
LID - e0237193
AB  - BACKGROUND: The myocardial adaptive mechanism in patients with repaired tetralogy 
      of Fallot (rTOF) is less understood. We aimed to investigate biventricular 
      myocardial adaptive remodeling in rTOF patients. METHODS: We recruited 32 rTOF 
      patients and 38 age- and sex-matched normal controls. The pulmonary stenosis of 
      rTOF patients was measured using catheterized pressure gradient between right 
      ventricle (RV) and pulmonary artery (PGRVPA). rTOF patients with PGRVPA < 15 mmHg 
      and >/=15 mmHg were classified as low pulmonary stenosis (rTOFlow, n = 19) and high 
      pulmonary stenosis (rTOFhigh, n = 13) subgroups, respectively. Magnetic resonance 
      imaging tissue phase mapping was employed to evaluate the voxelwise biventricular 
      myocardial motion in longitudinal (Vz), radial (Vr), and circumferential (Vphi) 
      directions. RESULTS: The rTOFlow subgroup presented higher pulmonary 
      regurgitation fraction than rTOFhigh subgroup (p < 0.001). Compared with the 
      normal group, only rTOFlow subgroup presented a decreased RV ejection fraction 
      (RVEF) (p < 0.05). The rTOFlow subgroup showed decreased systolic and diastolic 
      Vz in RV and LV, whereas rTOFhigh subgroup showed such change only in RV. In 
      rTOFlow subgroup, RVEF significantly correlated with RV systolic Vr (r = 0.56, p 
      < 0.05), whereas LVEF correlated with LV systolic Vz (r = 0.51, p = 0.02). 
      Prolonged QRS correlated with RV systolic Vr (r = -0.58, p < 0.01) and LV 
      diastolic Vr (r = 0.81, p < 0.001). No such correlations occurred in rTOFhigh 
      subgroup. CONCLUSIONS: The avoidance of unfavorable functional interaction in RV 
      and LV in rTOFhigh subgroup suggested that adequate pulmonary stenosis (PGRVPA >/= 
      15 mmHg in this sereis) has a protective effect against pulmonary regurgitation.
FAU - Chang, Meng-Chu
AU  - Chang MC
AD  - Department of Biomedical Engineering and Environmental Sciences, National Tsing 
      Hua University, Hsinchu, Taiwan.
FAU - Wu, Ming-Ting
AU  - Wu MT
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
AD  - Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
FAU - Weng, Ken-Pen
AU  - Weng KP
AUID- ORCID: 0000-0002-0649-1803
AD  - Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
AD  - Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
AD  - Department of Physical Therapy, Shu-Zen College of Medicine and Management, 
      Kaohsiung, Taiwan.
FAU - Chien, Kuang-Jen
AU  - Chien KJ
AD  - Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
FAU - Lin, Chu-Chuan
AU  - Lin CC
AD  - Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
FAU - Su, Mao-Yuan
AU  - Su MY
AD  - Department of Medical Imaging, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Lin, Ko-Long
AU  - Lin KL
AD  - Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General 
      Hospital, Kaohsiung, Taiwan.
FAU - Chang, Ming-Hua
AU  - Chang MH
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
FAU - Peng, Hsu-Hsia
AU  - Peng HH
AD  - Department of Biomedical Engineering and Environmental Sciences, National Tsing 
      Hua University, Hsinchu, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200811
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Exercise Test
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pulmonary Valve Insufficiency/*diagnostic imaging/physiopathology
MH  - Pulmonary Valve Stenosis/*diagnostic imaging/physiopathology
MH  - Stroke Volume
MH  - Tetralogy of Fallot/*diagnostic imaging/physiopathology/*rehabilitation/surgery
MH  - Ventricular Dysfunction, Left/physiopathology
MH  - Ventricular Dysfunction, Right/physiopathology
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
MH  - Young Adult
PMC - PMC7418997
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/08/12 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/08/11
CRDT- 2020/08/12 06:00
PHST- 2020/03/11 00:00 [received]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/12 06:00 [entrez]
PHST- 2020/08/12 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/08/11 00:00 [pmc-release]
AID - PONE-D-20-07072 [pii]
AID - 10.1371/journal.pone.0237193 [doi]
PST - epublish
SO  - PLoS One. 2020 Aug 11;15(8):e0237193. doi: 10.1371/journal.pone.0237193. 
      eCollection 2020.