PMID- 32781843
OWN - NLM
STAT- MEDLINE
DCOM- 20210908
LR  - 20210908
IS  - 1532-7914 (Electronic)
IS  - 0163-5581 (Linking)
VI  - 73
IP  - 9
DP  - 2021
TI  - Comparing the In Vitro Antitumor, Antioxidant and Anti-Inflammatory Activities 
      between Two New Very Long Chain Polyunsaturated Fatty Acids, Docosadienoic Acid 
      (DDA) and Docosatrienoic Acid (DTA), and Docosahexaenoic Acid (DHA).
PG  - 1697-1707
LID - 10.1080/01635581.2020.1804949 [doi]
AB  - Very long chain polyunsaturated fatty acids (VLCPUFAs) are widely used as 
      nutraceutical supplements for human health. Recently, a high level of two new 
      VLCPUFAs, docosadienoic acid (DDA, 22:2n-6) and docosatrienoic acid (DTA, 
      22:3n-3), was produced in oilseed crop Brassica carinata using a biotechnology 
      approach. This study investigated the functional properties of these two VLCPUFAs 
      in human cells. Compared to docosahexaenoic acid (DHA), the golden standard in 
      evaluating the health-promoting activities of VLCPUFAs, both DDA and DTA 
      exhibited comparable or even better antitumor and antioxidant effects against 
      human breast cancer SK-BR-3 and MDA-MB-231 cells. Especially, DTA elicited much 
      stronger antioxidant and pro-apoptotic effects than DHA. Furthermore, DDA and DTA 
      showed strong anti-inflammatory effects in human macrophages differentiated from 
      monocyte THP-1 cells through lowering the protein expression levels of 
      pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), 
      interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor 
      necrosis factor alpha (TNF-alpha). Future In Vivo and In Vivo studies are warranted to 
      identify the mechanism of action (MOA) for the antitumor, antioxidant and 
      anti-inflammatory functions of DDA and DTA and explore potential applications of 
      these two VLCPUFAs as novel nutraceutical supplements in preventing inflammatory 
      conditions, aging and even cancer.
FAU - Chen, Yi
AU  - Chen Y
AD  - Department of Food and Bioproduct Sciences, College of Agriculture and 
      Bioresources, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Qiu, Xiao
AU  - Qiu X
AD  - Department of Food and Bioproduct Sciences, College of Agriculture and 
      Bioresources, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Yang, Jian
AU  - Yang J
AD  - Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, 
      University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200811
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 25167-62-8 (Docosahexaenoic Acids)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology
MH  - *Antioxidants/pharmacology
MH  - *Docosahexaenoic Acids/pharmacology
MH  - Fatty Acids, Unsaturated/pharmacology
MH  - Humans
MH  - Macrophages
EDAT- 2020/08/13 06:00
MHDA- 2021/09/09 06:00
CRDT- 2020/08/13 06:00
PHST- 2020/08/13 06:00 [pubmed]
PHST- 2021/09/09 06:00 [medline]
PHST- 2020/08/13 06:00 [entrez]
AID - 10.1080/01635581.2020.1804949 [doi]
PST - ppublish
SO  - Nutr Cancer. 2021;73(9):1697-1707. doi: 10.1080/01635581.2020.1804949. Epub 2020 
      Aug 11.