PMID- 32781959
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 17
IP  - 6
DP  - 2020
TI  - Exploring Shared Pathogenesis of Alzheimer's Disease and Type 2 Diabetes Mellitus 
      via Co-expression Networks Analysis.
PG  - 566-575
LID - 10.2174/1567205017666200810164932 [doi]
AB  - BACKGROUND: Alzheimer's Disease (AD) and Type 2 Diabetes Mellitus (T2DM) have an 
      increased incidence in modern society. Although increasing evidence has supported 
      the close linkage between these two disorders, the inter-relational mechanisms 
      remain to be fully elucidated. OBJECTIVE: The primary purpose of this study is to 
      explore the shared pathophysiological mechanisms of AD and T2DM. METHODS: We 
      downloaded the microarray data of AD and T2DM from the Gene Expression Omnibus 
      (GEO) database and constructed co-expression networks by Weighted Gene 
      Co-Expression Network Analysis (WGCNA) to identify gene network modules related 
      to AD and T2DM. Then, Gene Ontology (GO) and pathway enrichment analysis were 
      performed on the common genes existing in the AD and T2DM related modules by 
      clusterProfiler and DOSE package. Finally, we utilized the STRING database to 
      construct the protein-protein interaction network and found out the hub genes in 
      the network. RESULTS: Our findings indicated that seven and four modules were the 
      most significant with AD and T2DM, respectively. Functional enrichment analysis 
      showed that AD and T2DM common genes were mainly enriched in signaling pathways 
      such as circadian entrainment, phagosome, glutathione metabolism and synaptic 
      vesicle cycle. Protein-protein interaction network construction identified 10 hub 
      genes (CALM1, LRRK2, RBX1, SLC6A1, TXN, SNRPF, GJA1, VWF, LPL, AGT) in AD and 
      T2DM shared genes. CONCLUSION: Our work identified common pathogenesis of AD and 
      T2DM. These shared pathways might provide a novel idea for further mechanistic 
      studies and hub genes that may serve as novel therapeutic targets for diagnosis 
      and treatment of AD and T2DM.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Zhu, Yukun
AU  - Zhu Y
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Sciences, Tianjin Medical University, Tianjin, China.
FAU - Ding, Xuelu
AU  - Ding X
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Sciences, Tianjin Medical University, Tianjin, China.
FAU - She, Zhaoyuan
AU  - She Z
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Sciences, Tianjin Medical University, Tianjin, China.
FAU - Bai, Xue
AU  - Bai X
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Sciences, Tianjin Medical University, Tianjin, China.
FAU - Nie, Ziyang
AU  - Nie Z
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Sciences, Tianjin Medical University, Tianjin, China.
FAU - Wang, Feng
AU  - Wang F
AD  - Department of Genetics, School of Basic Medical Sciences, Tianjin Medical 
      University, Tianjin, China.
FAU - Wang, Fei
AU  - Wang F
AD  - Department of Neurology, General Hospital, Tianjin Medical University, Tianjin, 
      China.
FAU - Geng, Xin
AU  - Geng X
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Sciences, Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
SB  - IM
MH  - Alzheimer Disease/complications/*etiology/genetics
MH  - Diabetes Mellitus, Type 2/complications/*etiology/genetics
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Protein Interaction Maps
MH  - Risk Factors
MH  - Transcriptome
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Hub gene
OT  - WGCNA
OT  - functional enrichment analysis
OT  - protein-protein Interaction network
OT  - type 2 diabetes mellitus
EDAT- 2020/08/13 06:00
MHDA- 2023/02/25 06:00
CRDT- 2020/08/13 06:00
PHST- 2020/01/10 00:00 [received]
PHST- 2020/06/16 00:00 [revised]
PHST- 2020/06/17 00:00 [accepted]
PHST- 2020/08/13 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2020/08/13 06:00 [entrez]
AID - CAR-EPUB-109016 [pii]
AID - 10.2174/1567205017666200810164932 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2020;17(6):566-575. doi: 10.2174/1567205017666200810164932.