PMID- 32785694
OWN - NLM
STAT- MEDLINE
DCOM- 20210216
LR  - 20210216
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 105
IP  - 11
DP  - 2020 Nov 1
TI  - Serum Parathyroid Hormone Predicts Mortality in Coronary Angiography Patients 
      with Type 2 Diabetes.
LID - dgaa512 [pii]
LID - 10.1210/clinem/dgaa512 [doi]
AB  - BACKGROUND: Elevated serum levels of parathyroid hormone (PTH), one of the main 
      regulators of calcium homeostasis and vitamin D metabolism, have been proposed as 
      predictors of mortality. The impact of type 2 diabetes mellitus (T2DM) on the 
      putative association between PTH and mortality has not been investigated thus 
      far. AIM: The aim of our study was to investigate the impact of T2DM on the power 
      of PTH to predict mortality risk. METHODS: Serum PTH levels were determined in 
      904 consecutive Caucasian patients referred to coronary angiography for the 
      evaluation of established or suspected stable coronary artery disease (CAD), 
      including 235 patients with T2DM. Prospectively, deaths were recorded over a mean 
      follow-up period of 6.3 years. RESULTS: PTH at baseline did not differ 
      significantly between patients with and without T2DM (P = .307). Cox regression 
      analysis revealed that the serum PTH level strongly predicted all-cause mortality 
      in patients with T2DM (hazard ratio [HR] = 2.35 [1.37-4.03]; P = .002), whereas 
      PTH did not predict all-cause mortality in patients without T2DM (HR = 1.04 
      [0.81-1.32]; P = .766). The interaction term PTH x T2DM was significant 
      (P = .006), indicating a significantly stronger impact of PTH on mortality risk 
      in patients with T2DM than in individuals without diabetes. The impact of PTH on 
      mortality risk in patients with T2DM remained significant after adjustment for 
      glycated hemoglobin A1c, diabetes duration, classical cardiovascular risk 
      factors, serum levels of vitamin D, and kidney function (HR = 2.10 [1.10-4.10]; 
      P = .030). CONCLUSION: We conclude that PTH is a significantly stronger predictor 
      of all-cause mortality in patients with T2DM than in those without T2DM.
CI  - (c) Endocrine Society 2020. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Brandtner, Eva Maria
AU  - Brandtner EM
AD  - Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, 
      Austria.
FAU - Muendlein, Axel
AU  - Muendlein A
AD  - Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, 
      Austria.
FAU - Leiherer, Andreas
AU  - Leiherer A
AD  - Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, 
      Austria.
AD  - Medical Central Laboratories, Feldkirch, Austria.
AD  - Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
FAU - Armbruster, Franz Paul
AU  - Armbruster FP
AD  - Immundiagnostik AG, Bensheim, Germany.
FAU - Dschietzig, Thomas Bernd
AU  - Dschietzig TB
AD  - Immundiagnostik AG, Bensheim, Germany.
FAU - Geiger, Kathrin
AU  - Geiger K
AD  - Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, 
      Austria.
AD  - Medical Central Laboratories, Feldkirch, Austria.
FAU - Fraunberger, Peter
AU  - Fraunberger P
AD  - Medical Central Laboratories, Feldkirch, Austria.
FAU - Saely, Christoph H
AU  - Saely CH
AD  - Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, 
      Austria.
AD  - Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
AD  - Department of Internal Medicine I, Academic Teaching Hospital Feldkirch, 
      Feldkirch, Austria.
FAU - Drexel, Heinz
AU  - Drexel H
AD  - Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, 
      Austria.
AD  - Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.
AD  - Drexel University College of Medicine, Philadelphia, Pennsylvania.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Parathyroid Hormone)
SB  - IM
MH  - Aged
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/complications/diagnostic imaging
MH  - Diabetes Mellitus, Type 2/blood/complications/*mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/*blood
MH  - Risk
MH  - Risk Assessment
EDAT- 2020/08/14 06:00
MHDA- 2021/02/17 06:00
CRDT- 2020/08/14 06:00
PHST- 2020/04/29 00:00 [received]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2020/08/14 06:00 [pubmed]
PHST- 2021/02/17 06:00 [medline]
PHST- 2020/08/14 06:00 [entrez]
AID - 5891791 [pii]
AID - 10.1210/clinem/dgaa512 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa512. doi: 10.1210/clinem/dgaa512.