PMID- 32785783
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20220531
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 278
IP  - 6
DP  - 2021 Jun
TI  - Is otitis media with effusion associated with Samter's triad a new nosological 
      entity? A preliminary report on inflammatory mediator production.
PG  - 1835-1843
LID - 10.1007/s00405-020-06276-1 [doi]
AB  - PURPOSE: Otitis media with effusion (OME) associated with Samter's triad (ST) is 
      a difficult entity to treat. The aim of study was an investigation of the middle 
      ear and nasal production of inflammatory mediators (IM) in patients with ST and 
      analysing differences between them and controls. METHODS: Prospective 
      case-control study. Nineteen patients with OME (five had allergic rhinitis, four 
      had nasopharyngeal lymphoid hyperplasia, five had no evident sino-nasopharyngeal 
      disease and five had confirmed ST) and 15 healthy participants were included. The 
      concentrations of IM interleukin-1 beta (IL-1beta), interferon-alpha 2 (IFN-alpha2), 
      interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1), IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, 
      IL-23 and IL-33 were measured in nasal and middle ear secretions. RESULTS: There 
      was a difference that was close to a level of statistical significance only for 
      IL-1beta levels in middle ear fluid (p = 0.052) between the ST subgroup and the 
      other patients with OME. Also, we found a significant difference for IL-23 in 
      nasal secretions between these subgroups (p = 0.040), whereas the difference in 
      nasal fluid IL-33 was close to a level of statistical significance (p = 0.052). 
      There was a significant difference in nasal concentrations of IL-1beta, IFN-alpha2, 
      MCP-1, IL-8, IL-18 and IL-33 (p < 0.001, p = 0.005, p = 0.008, p = 0.011, 
      p = 0.011 and p = 0.011, respectively) between the OME group and the healthy 
      subjects. There were significant positive correlations between concentrations of 
      IL-1beta, IFN-alpha2, IFN-gamma, TNF-alpha, MCP-1, IL-17A, IL-18 and IL-33 (p < 0.001, 
      p < 0.001, p = 0.002, p = 0.028, p < 0.001, p < 0.001, p < 0.001 and p < 0.001, 
      respectively) in nasal and middle ear secretions. CONCLUSION: This preliminary 
      report showed some differences in IM production between the patients with OME 
      associated with ST and those without it. Our results suggest a uniformity of the 
      production of nasal and middle ear IM and supported the concept of a united 
      airway respiratory disease.
FAU - Cvorovic, Ljiljana
AU  - Cvorovic L
AUID- ORCID: 0000-0003-3783-1708
AD  - Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and 
      Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 
      2, 11000, Belgrade, Serbia. ljiljana.cvorovic.kcs@gmail.com.
FAU - Trivic, Aleksandar
AU  - Trivic A
AD  - Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and 
      Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 
      2, 11000, Belgrade, Serbia.
FAU - Dudvarski, Zoran
AU  - Dudvarski Z
AD  - Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and 
      Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 
      2, 11000, Belgrade, Serbia.
FAU - Jotic, Ana
AU  - Jotic A
AD  - Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and 
      Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 
      2, 11000, Belgrade, Serbia.
FAU - Folic, Miljan
AU  - Folic M
AD  - Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and 
      Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 
      2, 11000, Belgrade, Serbia.
FAU - Arsovic, Nenad
AU  - Arsovic N
AD  - Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and 
      Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 
      2, 11000, Belgrade, Serbia.
FAU - Bukumiric, Zoran
AU  - Bukumiric Z
AD  - Faculty of Medicine, Institute for Medical Statistics, University of Belgrade, 
      Belgrade, Serbia.
FAU - Grgurevic, Ugljesa
AU  - Grgurevic U
AD  - Department of Otorhinolaryngology, Military Medical Academy Faculty of Medicine, 
      Belgrade, Serbia.
FAU - Vojvodic, Danilo
AU  - Vojvodic D
AD  - Division of Clinical and Experimental Immunology, Military Medical Academy 
      Faculty of Medicine, Institute for Medical Research, Belgrade, Serbia.
FAU - Peric, Aleksandar
AU  - Peric A
AD  - Department of Otorhinolaryngology, Military Medical Academy Faculty of Medicine, 
      Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20200812
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Cytokines)
SB  - IM
MH  - Case-Control Studies
MH  - Cytokines/*analysis
MH  - Ear, Middle
MH  - Humans
MH  - *Otitis Media with Effusion/complications/diagnosis
MH  - Prospective Studies
OTO - NOTNLM
OT  - Aspirin-exacerbated respiratory disease
OT  - Eosinophilic otitis media
OT  - Inflammatory mediators
OT  - Otitis media with effusion
OT  - Samter's triad
EDAT- 2020/08/14 06:00
MHDA- 2021/05/21 06:00
CRDT- 2020/08/14 06:00
PHST- 2019/04/21 00:00 [received]
PHST- 2020/08/05 00:00 [accepted]
PHST- 2020/08/14 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2020/08/14 06:00 [entrez]
AID - 10.1007/s00405-020-06276-1 [pii]
AID - 10.1007/s00405-020-06276-1 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2021 Jun;278(6):1835-1843. doi: 
      10.1007/s00405-020-06276-1. Epub 2020 Aug 12.