PMID- 32785807 OWN - NLM STAT- MEDLINE DCOM- 20210916 LR - 20210916 IS - 1352-8661 (Electronic) IS - 0968-5243 (Linking) VI - 34 IP - 3 DP - 2021 Jun TI - OPERA: a novel method to reduce ghost and aliasing artifacts. PG - 451-467 LID - 10.1007/s10334-020-00881-1 [doi] AB - OBJECTIVE: A method for Orthogonal Phase Encoding Reduction of Artifact (OPERA) was developed and tested. MATERIALS AND METHODS: Because the position of ghosts and aliasing artifacts is predictable along columns or rows, OPERA combines the intensity values of two images acquired using the same parameters, but with swapped phase-encoding directions, to correct the artifacts. Simulations and phantom experiments were conducted to define the efficacy, robustness, and reproducibility. Clinical validation was performed on a total of 1003 images by comparing the OPERA-corrected images and the corresponding image standard in terms of Signal-to-Noise Ratio (SNR) and Contrast-to-Noise Ratio (CNR). The method efficacy was also rated using a Likert-type scale response by two experienced independent radiologists using a single-blinded procedure. RESULTS: Simulations and phantom experiments demonstrated the robustness and effectiveness of OPERA in reducing artifacts strength. OPERA application did not significantly change the SNR [+ 4.16%; inter-quartile range (IQR): 2.72-5.01%] and CNR (+ 4.30%; IQR: 2.86-6.04%) values. The two radiologists observed a total of 893 original images with artifacts (89.03% of the total images), a reduction in the perceived artifacts of 82.0% and 83.9% (p < 0.0001), and an improvement in the perceived SNR (82.8% and 88.5%; K = 0.714) and perceived CNR (86.9-88.9%; K = 0.722). DISCUSSION: The study demonstrated that OPERA reduces MR artifacts and improves the perceived image quality. FAU - Dell'Orso, Andrea AU - Dell'Orso A AUID- ORCID: 0000-0001-7135-3442 AD - Department of Radiology, San Giuseppe Hospital, Empoli AO Toscana Centro, Viale Boccaccio 14, Florence, Italy. dellorsoandrea@gmail.com. FAU - Positano, Vincenzo AU - Positano V AD - Fondazione G. Monasterio CNR - Regione Toscana, Pisa, Italy. FAU - Arisi, Giovanni AU - Arisi G AD - Blue Soft Software Solutions, Poggibonsi, Italy. FAU - d'Errico, Francesco AU - d'Errico F AD - Universita di Pisa, Scuola di Ingegneria, Pisa, Italy. AD - School of Medicine, Yale University, New Haven, CT, USA. FAU - Taddei, Aldo AU - Taddei A AD - Clinical Department of Radiology, AO Toscana SUD-EST, Poggibonsi General Hospital, Poggibonsi, Italy. FAU - Banchi, Benedetta AU - Banchi B AD - Department of Radiology, University of Siena, Siena, Italy. FAU - De Felice, Claudio AU - De Felice C AD - AOUS, Neonatal Intensive Care Unit, S.M. Alle Scotte General Hospital, Siena, Italy. LA - eng PT - Journal Article DEP - 20200812 PL - Germany TA - MAGMA JT - Magma (New York, N.Y.) JID - 9310752 SB - IM MH - *Artifacts MH - Phantoms, Imaging MH - Reproducibility of Results MH - Signal-To-Noise Ratio OTO - NOTNLM OT - Aliasing OT - Ghost artifact OT - Image quality OT - MRI OT - Phase-encoding direction EDAT- 2020/08/14 06:00 MHDA- 2021/09/18 06:00 CRDT- 2020/08/14 06:00 PHST- 2020/04/21 00:00 [received] PHST- 2020/08/03 00:00 [accepted] PHST- 2020/06/29 00:00 [revised] PHST- 2020/08/14 06:00 [pubmed] PHST- 2021/09/18 06:00 [medline] PHST- 2020/08/14 06:00 [entrez] AID - 10.1007/s10334-020-00881-1 [pii] AID - 10.1007/s10334-020-00881-1 [doi] PST - ppublish SO - MAGMA. 2021 Jun;34(3):451-467. doi: 10.1007/s10334-020-00881-1. Epub 2020 Aug 12.