PMID- 32787363
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 9
IP  - 5
DP  - 2020 Sep
TI  - Preliminary exploration on the role of clinical pharmacists in cancer pain 
      pharmacotherapy.
PG  - 3070-3077
LID - 10.21037/apm-20-627 [doi]
AB  - BACKGROUND: More than half of cancer patients affected by cancer experience pain 
      of moderate-tosevere intensity. Therefore, facilitating appropriate and safe 
      administration of analgesics is crucial to the comprehensive management of cancer 
      patients. In this article, we assessed medication adherence, pain relief, drug 
      related problems (DRPs) and analgesics adverse events (AEs) in cancer pain 
      patients based on a model of clinical pharmacy services. METHODS: In this 
      prospective, single-arm intervention study, cancer pain patients admitted to our 
      institution were eligible. According to different adherence, heterogeneity of 
      pain, and individual treatment strategy, clinical pharmacists (CPs) provided 
      comprehensive pain assessment and medication education for patients, as well as 
      provided consultation and recommendation for physicians. CPs' pharmacy services 
      were assessed through medication adherence, numbers of DRPs, acceptance of 
      recommendation, pain intensity (PI), daily interference and AEs. RESULTS: A total 
      of 42 patients were enrolled between November, 2018 and November, 2019. Compared 
      to baseline, patients' medication adherence evaluated with a medication adherence 
      scale showed a significantly improvement at 14 and at 28 days after receiving 
      CPs' interventions (8 score vs. 7 score at 14 days and at 28 days, P<0.01). 
      During the 28-day follow-up, a total of 63 interventions were put forward 
      according to 57 identified DRPs in 33 patients (78.6%), and approximately 95% 
      (60/63) of the interventions were accepted by physicians. PI and daily 
      interference significantly improved on the third day after the interventions of 
      CPs, and the improvement continued until day 28 (P<0.01). AEs caused by opioids 
      occurred in 19 patients (45.2%), and the most common one was constipation (14 
      patients, 33.3%). CONCLUSIONS: CPs' comprehensive interventions for cancer pain 
      patients were efficacious in improving their medication adherence and pain 
      relief, as well as reducing incidence of AEs. Therefore, this promising model 
      should be replicated in other medical centers.
FAU - Su, Ying-Jie
AU  - Su YJ
AD  - Department of Pharmacy, Department of Radiation Oncology, Renji Hospital, School 
      of Medicine, Shanghai Jiaotong University, Shanghai, China.
FAU - Yan, Yi-Dan
AU  - Yan YD
AD  - Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai, China.
FAU - Wang, Wen-Juan
AU  - Wang WJ
AD  - Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, China.
FAU - Xu, Tao
AU  - Xu T
AD  - Department of Pharmacy, Ningbo First Hospital, Ningbo, China.
FAU - Gu, Zhi-Chun
AU  - Gu ZC
AD  - Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai, China. guzhichun213@163.com.
FAU - Bai, Yong-Rui
AU  - Bai YR
AD  - Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, Shanghai, China. baiyongrui@renji.com.
FAU - Lin, Hou-Wen
AU  - Lin HW
AD  - Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20200804
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
SB  - IM
MH  - *Cancer Pain/drug therapy
MH  - Humans
MH  - Medication Adherence
MH  - *Neoplasms/drug therapy
MH  - Pharmacists
MH  - *Pharmacy Service, Hospital
MH  - Prospective Studies
OTO - NOTNLM
OT  - Cancer pain
OT  - adherence
OT  - clinical pharmacist (CP)
OT  - drug related problems (DRPs)
OT  - pharmacy services
EDAT- 2020/08/14 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/08/14 06:00
PHST- 2020/03/12 00:00 [received]
PHST- 2020/06/23 00:00 [accepted]
PHST- 2020/08/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/08/14 06:00 [entrez]
AID - apm-20-627 [pii]
AID - 10.21037/apm-20-627 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2020 Sep;9(5):3070-3077. doi: 10.21037/apm-20-627. Epub 2020 Aug 
      4.