PMID- 32787816
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20210524
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Aug 12
TI  - Association between tumor necrosis factor alpha and obstructive sleep apnea in 
      adults: a meta-analysis update.
PG  - 215
LID - 10.1186/s12890-020-01253-0 [doi]
LID - 215
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) has been reported to play a part in 
      the development of obstructive sleep apnea (OSA) and its complications. However, 
      the relationship between TNF-alpha and OSA still remains inconclusive. We aimed to 
      systematically review and synthesize studies published to date on association 
      between the two in adults. METHODS: We searched for English-language articles 
      containing original human data from case-control study studies in adults>/=18 years 
      of age. The selection criteria were set according to the PICOS framework. 
      Articles were independently reviewed by three investigators. Data regarding 
      demographics, clinical characteristics, and TNF-alpha levels were obtained. A 
      random-effects model was applied to evaluate the overall effect sizes by 
      calculating standard mean difference (SMD) and its 95% confidence intervals 
      (CIs). RESULTS: Of 393 identified abstracts, 50 articles (3503 OSA patients and 
      3379 health controls) were ultimately included in this meta-analysis. The results 
      indicated that the TNF-alpha level in patients with OSA was 1.77 (95%CI, 1.37 to 
      2.17, I(2) = 97.8%, P < 0.0001) times higher than in the control group. Subgroup 
      analyses showed a positive correlation between the level of TNF-alpha and OSA 
      severity. According to meta-regression, we noted that aging significantly 
      predicted an increased effect size of TNF-alpha level in OSA patients (P < 0.007). 
      CONCLUSION: This study identified a significant association between OSA and 
      elevated TNF-alpha level in adults. Meanwhile, TNF-alpha levels were consistently 
      correlated with severity of OSA, which indicated it might be a promising 
      biomarker for the development of OSA. However, well-designed, large-scale, 
      case-control cohorts are needed to better understand the relationship of TNF-alpha in 
      the context of adult OSA.
FAU - Cao, Yuan
AU  - Cao Y
AD  - Department of Pulmonary and Critical Care Medicine, The Second Affiliated 
      Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi, China.
FAU - Song, Yali
AU  - Song Y
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, China.
FAU - Ning, Pu
AU  - Ning P
AD  - Department of Pulmonary and Critical Care Medicine, The Second Affiliated 
      Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi, China.
FAU - Zhang, Liyu
AU  - Zhang L
AD  - Institute of Pediatric Diseases, The Affiliated Children Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Wu, Shuang
AU  - Wu S
AD  - Clinical Laboratory, The Affiliated Children Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Quan, Juan
AU  - Quan J
AD  - Department of Ultrasound, School of Medicine, The Second Affiliated Hospital of 
      Zhejiang University, Zhejiang, Hangzhou, China.
FAU - Li, Qiao
AU  - Li Q
AUID- ORCID: 0000-0002-2575-7005
AD  - Clinical Laboratory, The Affiliated Children Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China. liqiao@csu.edu.cn.
LA  - eng
GR  - Program No.2020JQ-543; 2020JQ-927/Natural Science Basic Research Plan in 
      Shaanxi Province of China /
GR  - 2019YJ0067/Natural Science Foundation of Sichuan Province/
GR  - xzy012019129/Fundamental Research Funds for the Central Universities under Grant/
GR  - SF1510(4)/Xi'an Science and Technology program/
GR  - J20170219II/Xi'an Science and Technology program under Grant/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200812
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung/physiopathology
MH  - Sleep Apnea, Obstructive/*blood/diagnosis/physiopathology
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC7425010
OTO - NOTNLM
OT  - Meta-analysis
OT  - Obstructive sleep apnea
OT  - Tumor necrosis factor-alpha
COIS- The authors declare that there is no conflict of interests regarding the 
      publication of this paper.
EDAT- 2020/08/14 06:00
MHDA- 2021/05/25 06:00
PMCR- 2020/08/12
CRDT- 2020/08/14 06:00
PHST- 2019/12/28 00:00 [received]
PHST- 2020/08/05 00:00 [accepted]
PHST- 2020/08/14 06:00 [entrez]
PHST- 2020/08/14 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2020/08/12 00:00 [pmc-release]
AID - 10.1186/s12890-020-01253-0 [pii]
AID - 1253 [pii]
AID - 10.1186/s12890-020-01253-0 [doi]
PST - epublish
SO  - BMC Pulm Med. 2020 Aug 12;20(1):215. doi: 10.1186/s12890-020-01253-0.