PMID- 32788085
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20240330
IS  - 2451-9030 (Electronic)
IS  - 2451-9022 (Print)
IS  - 2451-9022 (Linking)
VI  - 6
IP  - 2
DP  - 2021 Feb
TI  - Neuroimaging Markers of Resiliency in Youth at Clinical High Risk for Psychosis: 
      A Qualitative Review.
PG  - 166-177
LID - S2451-9022(20)30139-7 [pii]
LID - 10.1016/j.bpsc.2020.06.002 [doi]
AB  - Psychotic disorders are highly debilitating and constitute a major public health 
      burden. Identifying markers of psychosis risk and resilience is a necessary step 
      toward understanding etiology and informing prevention and treatment efforts in 
      individuals at clinical high risk (CHR) for psychosis. In this context, it is 
      important to consider that neural risk markers have been particularly useful in 
      identifying mechanistic determinants along with predicting clinical outcomes. 
      Notably, despite a growing body of supportive literature and the promise of 
      recent findings identifying potential neural markers, the current work on CHR 
      resilience markers has received little attention. The present review provides a 
      brief overview of brain-based risk markers with a focus on predicting symptom 
      course. Next, the review turns to protective markers, examining research from 
      nonpsychiatric and schizophrenia fields to build an understanding of framing, 
      priorities, and potential, applying these ideas to contextualizing a small but 
      informative body of resiliency-relevant CHR research. Four domains 
      (neurocognition, emotion regulation, allostatic load, and sensory and 
      sensorimotor function) were identified and are discussed in terms of behavioral 
      and neural markers. Taken together, the literature suggests significant 
      predictive value for brain-based markers for individuals at CHR for psychosis, 
      and the limited but compelling resiliency work highlights the critical importance 
      of expanding this promising area of inquiry.
CI  - Copyright (c) 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Vargas, Teresa
AU  - Vargas T
AD  - Department of Psychology, Northwestern University, Evanston, Illinois. Electronic 
      address: teresavargas@u.northwestern.edu.
FAU - Damme, Katherine S F
AU  - Damme KSF
AD  - Department of Psychology, Northwestern University, Evanston, Illinois.
FAU - Ered, Arielle
AU  - Ered A
AD  - Department of Psychology, Temple University, Philadelphia, Pennsylvania.
FAU - Capizzi, Riley
AU  - Capizzi R
AD  - Department of Psychology, Temple University, Philadelphia, Pennsylvania.
FAU - Frosch, Isabelle
AU  - Frosch I
AD  - Department of Psychology, Northwestern University, Evanston, Illinois.
FAU - Ellman, Lauren M
AU  - Ellman LM
AD  - Department of Psychology, Temple University, Philadelphia, Pennsylvania.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology, Northwestern University, Evanston, Illinois; Department 
      of Psychiatry, Northwestern University, Evanston, Illinois; Department of Medical 
      Social Sciences, Northwestern University, Evanston, Illinois; Institute for 
      Policy Research, Northwestern University, Evanston, Illinois; Institute for 
      Innovations in Developmental Sciences, Northwestern University, Evanston, 
      Illinois.
LA  - eng
GR  - R01 MH112613/MH/NIMH NIH HHS/United States
GR  - F31 MH119776/MH/NIMH NIH HHS/United States
GR  - R21 MH110374/MH/NIMH NIH HHS/United States
GR  - R01 MH118545/MH/NIMH NIH HHS/United States
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
GR  - F31 MH119720/MH/NIMH NIH HHS/United States
GR  - R01 MH120091/MH/NIMH NIH HHS/United States
GR  - R01 MH120088/MH/NIMH NIH HHS/United States
GR  - R01 MH116039/MH/NIMH NIH HHS/United States
GR  - R21 MH119677/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20200610
PL  - United States
TA  - Biol Psychiatry Cogn Neurosci Neuroimaging
JT  - Biological psychiatry. Cognitive neuroscience and neuroimaging
JID - 101671285
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Biomarkers
MH  - Brain/diagnostic imaging
MH  - Humans
MH  - Neuroimaging
MH  - *Psychotic Disorders/diagnosis
MH  - *Schizophrenia
PMC - PMC7725930
MID - NIHMS1603429
OTO - NOTNLM
OT  - Biomarker
OT  - Clinical high risk for psychosis
OT  - Magnetic resonance imaging
OT  - Neuroimaging
OT  - Resilience
OT  - Schizophrenia
EDAT- 2020/08/14 06:00
MHDA- 2021/06/04 06:00
PMCR- 2022/02/01
CRDT- 2020/08/14 06:00
PHST- 2020/06/01 00:00 [received]
PHST- 2020/06/01 00:00 [revised]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/08/14 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2020/08/14 06:00 [entrez]
PHST- 2022/02/01 00:00 [pmc-release]
AID - S2451-9022(20)30139-7 [pii]
AID - 10.1016/j.bpsc.2020.06.002 [doi]
PST - ppublish
SO  - Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Feb;6(2):166-177. doi: 
      10.1016/j.bpsc.2020.06.002. Epub 2020 Jun 10.