PMID- 32789675
OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR  - 20220217
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 271
IP  - 8
DP  - 2021 Dec
TI  - Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in 
      the early postnatal mouse brain.
PG  - 1587-1591
LID - 10.1007/s00406-020-01180-5 [doi]
AB  - Rapastinel is a novel psychoactive substance that acts as an 
      N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and 
      antipsychotic-like effects in animal models. However, it is unknown if rapastinel 
      possesses a better side-effect profile than fast-acting glutamatergic 
      antidepressants, like ketamine, which trigger neurotoxicity in the perinatal 
      rodent cortex and protracted schizophrenia-like alterations. Here we found a 
      remarkable neuroprotective effect of rapastinel against apoptosis induced by the 
      NMDAR antagonist MK-801 in comparison to that elicited by clozapine and the 
      mGlu2/3 agonist LY354740. These results suggest the potential 
      therapeutic/prophylactic effect of rapastinel in ameliorating deleterious effects 
      induced by NMDAR blockade during neurodevelopment.
CI  - (c) 2020. Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Vasilescu, Andrei-Nicolae
AU  - Vasilescu AN
AD  - RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical Faculty Mannheim, Central Institute of Mental Health Mannheim, Heidelberg 
      University, J 5, 68159, Mannheim, Germany.
FAU - Mallien, Anne
AU  - Mallien A
AD  - RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical Faculty Mannheim, Central Institute of Mental Health Mannheim, Heidelberg 
      University, J 5, 68159, Mannheim, Germany.
FAU - Pfeiffer, Natascha
AU  - Pfeiffer N
AD  - RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical Faculty Mannheim, Central Institute of Mental Health Mannheim, Heidelberg 
      University, J 5, 68159, Mannheim, Germany.
FAU - Lang, Undine E
AU  - Lang UE
AD  - Department of Psychiatry (UPK), University of Basel, Wilhelm Klein Str. 27, 4002, 
      Basel, Switzerland.
FAU - Gass, Peter
AU  - Gass P
AD  - RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical Faculty Mannheim, Central Institute of Mental Health Mannheim, Heidelberg 
      University, J 5, 68159, Mannheim, Germany.
FAU - Inta, Dragos
AU  - Inta D
AD  - RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, 
      Medical Faculty Mannheim, Central Institute of Mental Health Mannheim, Heidelberg 
      University, J 5, 68159, Mannheim, Germany. Dragos.Inta@upk.ch.
AD  - Department of Psychiatry (UPK), University of Basel, Wilhelm Klein Str. 27, 4002, 
      Basel, Switzerland. Dragos.Inta@upk.ch.
LA  - eng
GR  - IN 168/3-1/Deutsche Forschungsgemeinschaft/
GR  - Neuron Cofund (ERA-NET NEURON NMDAR-PSY)/Bundesministerium fur Bildung und 
      Forschung/
PT  - Journal Article
DEP - 20200813
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6A1X56B95E (GLYX-13 peptide)
SB  - IM
MH  - Animals
MH  - *Cerebral Cortex/metabolism
MH  - Mice
MH  - *Neuroprotective Agents/pharmacology
MH  - *Oligopeptides/pharmacology
MH  - *Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - Antipsychotic drug
OT  - Caspase-3
OT  - MK-801
OT  - Neuroprotection
OT  - Neurotoxicity
OT  - Rapastinel
EDAT- 2020/08/14 06:00
MHDA- 2022/02/19 06:00
CRDT- 2020/08/14 06:00
PHST- 2020/04/15 00:00 [received]
PHST- 2020/07/31 00:00 [accepted]
PHST- 2020/08/14 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2020/08/14 06:00 [entrez]
AID - 10.1007/s00406-020-01180-5 [pii]
AID - 10.1007/s00406-020-01180-5 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2021 Dec;271(8):1587-1591. doi: 
      10.1007/s00406-020-01180-5. Epub 2020 Aug 13.