PMID- 32789805 OWN - NLM STAT- MEDLINE DCOM- 20201126 LR - 20210615 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 27 IP - 36 DP - 2020 Dec TI - Exposure to suboptimal ambient temperature during specific gestational periods and adverse outcomes in mice. PG - 45487-45498 LID - 10.1007/s11356-020-10416-9 [doi] AB - Exposure to suboptimal ambient temperature during pregnancy has been reported as a potential teratogen of fetal development. However, limited animal evidence is available regarding the impact of extreme temperatures on maternal pregnancy and the subsequent adverse pregnancy outcomes. Our objective in this study is to investigate the relationship between temperature and maternal stress during pregnancy in mice. This study used the Naval Medical Research Institute (NMRI) mice during the second and third pregnant weeks with the gestational day (GD) (GD 6.5-14.5 and GD 14.5-17.5). Mice were exposed to suboptimal ambient temperature (1 degrees C, 5 degrees C, 10 degrees C, 15 degrees C, 40 degrees C, 42 degrees C, 44 degrees C, 46 degrees C, and 48 degrees C for the experimental group and 23 degrees C for the control group) 1 h per day, 7 days a weekin each trimester. Measurements of placental development (placental weight [PW] and placental diameter [PD]) and fetal growth (fetal weight [FW] and crown-to-rump length [CRL]) between experimental and control groups were compared using analysis of variance (ANOVA). Data on the occurrence of preterm birth (PTB) and abnormalities were also collected. The results showed that exposure to both cold and heat stress in the second and third weeks of pregnancy caused significant decreases in measurements of placental development (PW and PD) and fetal growth (FW and CRL). For all temperature exposures, 15 degrees C was identified as the optimal temperature in the development of the embryo. Most PTB occurrences were observed in high-temperature stress groups, with the highest PTB number seen in the exposure group at 48 degrees C, whereas PTB occurred only at 1 degrees C among cold stress groups. In the selected exposure experiments, an approximate U-shaped relation was observed between temperature and number of abnormality occurrence. The highest percentage of these anomalies occurred at temperatures of 1 degrees C and 48 degrees C, while no abnormalities were observed at 15 degrees C and in the control group. Our findings strengthened the evidence that exposure to suboptimal ambient temperatures may trigger adverse pregnancy outcomes and worsen embryo and fetal development in mice. FAU - Mayvaneh, Fatemeh AU - Mayvaneh F AD - Faculty of Geography and Environmental Sciences, Hakim Sabzevari University, Khorasan Razavi, Sabzevar, 9617916487, Iran. FAU - Entezari, Alireza AU - Entezari A AD - Faculty of Geography and Environmental Sciences, Hakim Sabzevari University, Khorasan Razavi, Sabzevar, 9617916487, Iran. entezari@hsu.ac.ir. FAU - Sadeghifar, Fatemeh AU - Sadeghifar F AD - Department of Science, Hakim Sabzevari University, Khorasan Razavi, Sabzevar, 9617916487, Iran. FAU - Baaghideh, Mohammad AU - Baaghideh M AD - Faculty of Geography and Environmental Sciences, Hakim Sabzevari University, Khorasan Razavi, Sabzevar, 9617916487, Iran. FAU - Guo, Yuming AU - Guo Y AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Atabati, Azadeh AU - Atabati A AD - Faculty of Geography and Environmental Sciences, Hakim Sabzevari University, Khorasan Razavi, Sabzevar, 9617916487, Iran. FAU - Zhao, Qi AU - Zhao Q AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Zhang, Yunquan AU - Zhang Y AUID- ORCID: 0000-0002-2618-5088 AD - Department of Epidemiology and Biostatistics, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China. YunquanZhang@wust.edu.cn. AD - Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, 430065, China. YunquanZhang@wust.edu.cn. LA - eng PT - Journal Article DEP - 20200813 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 SB - IM MH - Animals MH - Crown-Rump Length MH - Female MH - Fetal Development MH - Mice MH - Pregnancy MH - Pregnancy Outcome MH - *Premature Birth MH - Temperature OTO - NOTNLM OT - Adverse birth outcomes OT - Fetal development OT - Maternal mortality OT - Mice OT - Suboptimal temperature EDAT- 2020/08/14 06:00 MHDA- 2020/11/27 06:00 CRDT- 2020/08/14 06:00 PHST- 2020/03/14 00:00 [received] PHST- 2020/08/05 00:00 [accepted] PHST- 2020/08/14 06:00 [pubmed] PHST- 2020/11/27 06:00 [medline] PHST- 2020/08/14 06:00 [entrez] AID - 10.1007/s11356-020-10416-9 [pii] AID - 10.1007/s11356-020-10416-9 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2020 Dec;27(36):45487-45498. doi: 10.1007/s11356-020-10416-9. Epub 2020 Aug 13.