PMID- 32790581 OWN - NLM STAT- MEDLINE DCOM- 20211124 LR - 20220531 IS - 1541-1087 (Electronic) IS - 0731-5724 (Linking) VI - 40 IP - 6 DP - 2021 Aug TI - Influence of Vitamin D Deficiency on the Development of Opportunistic Infection in People Living with HIV/AIDS (PWHAs). PG - 545-550 LID - 10.1080/07315724.2020.1805043 [doi] AB - BACKGROUND: It is known that vitamin D is associated with immune cell growth, and an association between vitamin D deficiency and development of chronic infections such as tuberculosis has been reported. However, there have been few studies concerning the association between vitamin D deficiency and opportunistic infection (OI) in people living with HIV/AIDS (PWHA). METHOD: PWHAs who had vitamin D (25-OH vitamin D, 25OHD) test results from 2012 to 2017 were enrolled. All enrolled PWHAs were divided into a vitamin D-deficient group and non-deficient group according to the 25OHD cutoff set by ROC curve analysis. The rates of OIs were compared between the two groups. RESULTS: Among 440 enrolled PWHAs, 394 (89.5%) were male, 32 were >/= 65 years (13.4%), 237 (53.9%) were ART-naive, and 107 (24.3%) had CD4 + T cell < 200/L. Seventy-three cases of OIs occurred in 63 PWHAs (14.3%); the most common OI was tuberculosis (27, 6.1%) followed by pneumocystis pneumonia (PCP) (25, 5.7%), and Cytomegalovirus (CMV) diseases (10, 2.3%). In the ROC curve analysis, the AUC was 0.71 (95% CI 0.64- 0.79, P < 0.001) and the optimal cutoffs of 25OHD to predict OIs was 14 ng/mL.Overall OI development was significantly more prevalent in the vitamin D-deficiency group (aOR 3.05, 95% CI 1.43-6.48); tuberculosis (aOR 3.51, 95% CI 1.22-10.05) and CMV disease (aOR 10.13, 95% CI 1.11-92.03) were significantly associated with vitamin D deficiency, whereas PCP was not (aOR 1.32, 95% CI 0.44-3.98). CONCLUSION: Stringent cutoffs of vitamin D deficiency (< 14 ng/mL) were well correlated with development of OIs in PWHAs. Vitamin D deficiency was associated with development of OIs, particularly tuberculosis and CMV infections. FAU - Lee, Shinwon AU - Lee S AD - Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. FAU - Lee, Jeong Eun AU - Lee JE AD - Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. FAU - Lee, Soon Ok AU - Lee SO AD - Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. FAU - Sim, Yong Ki AU - Sim YK AD - Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. FAU - Lee, Sun Hee AU - Lee SH AD - Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200813 PL - United States TA - J Am Coll Nutr JT - Journal of the American College of Nutrition JID - 8215879 SB - IM MH - *AIDS-Related Opportunistic Infections/epidemiology MH - *Acquired Immunodeficiency Syndrome/complications MH - Aged MH - CD4 Lymphocyte Count MH - Female MH - *HIV Infections/complications MH - Humans MH - Male MH - *Vitamin D Deficiency/complications OTO - NOTNLM OT - HIV/AIDS OT - Vitamin D OT - cytomegalovirus OT - infection OT - pneumocystis OT - tuberculosis EDAT- 2020/08/14 06:00 MHDA- 2021/11/25 06:00 CRDT- 2020/08/14 06:00 PHST- 2020/08/14 06:00 [pubmed] PHST- 2021/11/25 06:00 [medline] PHST- 2020/08/14 06:00 [entrez] AID - 10.1080/07315724.2020.1805043 [doi] PST - ppublish SO - J Am Coll Nutr. 2021 Aug;40(6):545-550. doi: 10.1080/07315724.2020.1805043. Epub 2020 Aug 13.