PMID- 32791699
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 30
DP  - 2020 Jul 24
TI  - The effectiveness and safety of traditional Chinese medicine for the treatment of 
      children with COVID-19.
PG  - e21247
LID - 10.1097/MD.0000000000021247 [doi]
LID - e21247
AB  - INTRODUCTION: With the widespread spread of novel coronavirus pneumonia, more and 
      more countries have been affected. Some research reports have shown that 
      traditional Chinese medicine has a significant effect on COVID-19 infection, and 
      the treatment of traditional Chinese medicine is used in some special people, 
      such as children. At present, there is a lack of high-quality systematic reviews 
      on the safety and efficacy of using Chinese medicine to treat children with novel 
      coronavirus pneumonia. MATERIALS AND METHODS: We will search Cochran library, 
      MEDLINE, EMBASE, China National Knowledge Infrastructure Database (CNKI), China 
      Biomedical Database (CBM), VIP Database (VIP), and Wanfang database for research. 
      This study includes randomized controlled trials (RCTs) and non-RCTs, and uses 
      the Cochrane systematic review to review the safety and efficacy of traditional 
      Chinese medicine in preventing and treating children with novel coronavirus 
      pneumonia. RCT research tools and quantitative research quality assessment tools 
      for non-randomized studies will be used to assess the risk of bias in studies 
      included in the systematic review. We will use Revman 5.3 software for 
      meta-analysis, the main result is odds ratio, and then a subgroup analysis will 
      be performed based on the age, intervention degree, and disease severity of the 
      patients reviewed. ETHICS AND DISSEMINATION: This systematic review protocol is 
      designed to provide evidence regarding the effectiveness and safety of 
      traditional Chinese medicine for the treatment of children with COVID-19, such 
      evidence may be useful and important for clinical treatment decisions. The 
      results should be disseminated through publication in a peer-reviewed journal. 
      Since the data and results used in the systematic review will be extracted 
      exclusively from published studies, approval from an ethics committee will not be 
      required. REGISTRATION INFORMATION: PROSPERO CRD42020179150.
FAU - Li, Yanqing
AU  - Li Y
AUID- ORCID: 0000-0003-4696-0069
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Bi, Lin
AU  - Bi L
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Li, Yulin
AU  - Li Y
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Hu, Xiongxin
AU  - Hu X
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Wang, Quanxi
AU  - Wang Q
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Liang, Xin
AU  - Liang X
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Yu, Xujun
AU  - Yu X
AD  - Chengdu University of Traditional Chinese Medicine.
FAU - Dong, Liang
AU  - Dong L
AD  - Department of Andrology, The Reproductive and Women-Children Hospital, Chengdu 
      University of Traditional Chinese Medicine.
FAU - Xie, Quan
AU  - Xie Q
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 
      P.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
EIN - Medicine (Baltimore). 2020 Aug 14;99(33):e21984. PMID: 32872085
MH  - Adolescent
MH  - *Betacoronavirus
MH  - COVID-19
MH  - Child
MH  - Child, Preschool
MH  - Coronavirus Infections/*drug therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Medicine, Chinese Traditional/*methods
MH  - Pandemics
MH  - Pneumonia, Viral/*drug therapy
MH  - Research Design
MH  - SARS-CoV-2
MH  - Systematic Reviews as Topic
MH  - Treatment Outcome
MH  - COVID-19 Drug Treatment
PMC - PMC7386965
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/08/15 06:00
MHDA- 2020/08/25 06:00
PMCR- 2020/07/24
CRDT- 2020/08/15 06:00
PHST- 2020/08/15 06:00 [entrez]
PHST- 2020/08/15 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2020/07/24 00:00 [pmc-release]
AID - 00005792-202007240-00045 [pii]
AID - MD-D-20-04179 [pii]
AID - 10.1097/MD.0000000000021247 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jul 24;99(30):e21247. doi: 
      10.1097/MD.0000000000021247.