PMID- 32791702
OWN - NLM
STAT- MEDLINE
DCOM- 20200824
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 30
DP  - 2020 Jul 24
TI  - Atopic dermatitis in Taiwanese children: The laboratory values that correlate 
      best to the SCORAD index are total IgE and positive Cheddar cheese IgE.
PG  - e21255
LID - 10.1097/MD.0000000000021255 [doi]
LID - e21255
AB  - Atopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease 
      associated with a personal or family history of atopic diseases. Determining the 
      objective severity scoring of AD index (SCORAD) and total immunoglobulin E (IgE) 
      to help to stage the severity (lesions extent and intensity of the lesions and 
      then the itch and sleep disturbance they may cause) of AD in children.In this 
      study, we adopted the SCORAD index, which consists of severity, area, and sleep 
      disturbance, to evaluate the AD status of children up to 18 years old. We 
      examined the blood levels of total serum IgE, white blood cell count/differential 
      count (WBC/DC), eosinophil counts (EC), eosinophil cationic protein (ECP) and 
      specific IgE.A total of 208 children with AD were enrolled in this study. Serum 
      IgE values and a number of specific IgE that are positive significantly different 
      SCORAD index through simple linear regression; however, after multiple linear 
      regression, only IgE values (95% CI: 0.001-0.004, P < .001), total WBC count (95% 
      CI: 0.112-1.736, P = .026), EC (95% CI: 0.045-6.706, P = .047), and specific IgE 
      to Cheddar cheese (95% CI: 1.814-16.731, P = .015) remain different. After 
      applying the Phi coefficient, we found that specific IgE to tuna (r = 0.632), 
      codfish (r = 0.613), and clam (r = 0.613) each had a moderate correlation with 
      specific IgE to Cheddar cheese. The 6 most common allergens were found to be mite 
      (D. Farinae: 65.9%), mite (D. Pterony: 64.9%), house dust (47.6%), cockroach mix 
      (37.0%), shrimp (30.8%), and crab (22.6%). Covariates of SCORAD index, severity, 
      area, and sleep disturbance differed.In this study, we found that total IgE 
      values, specific IgE values, WBC, EC, and specific IgE to Cheddar cheese have 
      significant correlations with SCORAD index in AD of Taiwanese children.
FAU - Kuo, Ho-Chang
AU  - Kuo HC
AD  - Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung 
      Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung.
FAU - Chu, Chi-Hsiang
AU  - Chu CH
AD  - Clinical Trial Center.
FAU - Su, Yu-Jih
AU  - Su YJ
AD  - Department of Internal Medicine.
FAU - Lee, Chih-Hung
AU  - Lee CH
AD  - Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, 83301, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/blood
MH  - Biomarkers/blood
MH  - Cheese/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*blood/etiology
MH  - Food Hypersensitivity/*blood/complications
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Leukocyte Count
MH  - Severity of Illness Index
MH  - Taiwan
PMC - PMC7387036
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/08/15 06:00
MHDA- 2020/08/25 06:00
PMCR- 2020/07/24
CRDT- 2020/08/15 06:00
PHST- 2020/08/15 06:00 [entrez]
PHST- 2020/08/15 06:00 [pubmed]
PHST- 2020/08/25 06:00 [medline]
PHST- 2020/07/24 00:00 [pmc-release]
AID - 00005792-202007240-00048 [pii]
AID - MD-D-20-00194 [pii]
AID - 10.1097/MD.0000000000021255 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jul 24;99(30):e21255. doi: 
      10.1097/MD.0000000000021255.