PMID- 32793312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 20
IP  - 4
DP  - 2020 Oct
TI  - MAGE-A genes as predictors of the outcome of laryngeal squamous cell carcinoma.
PG  - 59
LID - 10.3892/ol.2020.11920 [doi]
LID - 59
AB  - Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant 
      tumors in the head and neck area. Melanoma-associated antigens A (MAGE-A) are 
      strictly tumor-specific and are expressed in several types of tumors. To date, no 
      studies have reported the potential of MAGE-A genes as markers for circulating 
      tumor cells (CTCs) in patients with LSCC. The present study aimed to evaluate the 
      expression and the possible prognostic significance of MAGE-A in the peripheral 
      blood of patients with LSCC. In the present study, the expression of MAGE-A genes 
      was determined by multiplex semi-nested PCR and restriction endonuclease 
      treatment of the peripheral blood of patients with LSCC. The association between 
      MAGE-A gene expression and clinicopathological parameters and prognosis was 
      evaluated. The results demonstrated that the expression of MAGE-A was associated 
      with the predictors that indicate poor prognosis. The expression levels of MAGE-A 
      and each individual MAGE-A gene were also associated with a shorter overall 
      survival time of patients with LSCC. In conclusion, the results of the present 
      study suggested that the expression of MAGE-A genes may be a potential prognostic 
      marker for patients with LSCC.
CI  - Copyright (c) 2020, Spandidos Publications.
FAU - Liu, Shenghui
AU  - Liu S
AD  - Department of Otolaryngology, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, P.R. China.
AD  - Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 
      Hebei 050017, P.R. China.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - Department of Otolaryngology, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, P.R. China.
FAU - Xu, Yuru
AU  - Xu Y
AD  - Department of Otolaryngology, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, P.R. China.
FAU - Sang, Meixiang
AU  - Sang M
AD  - Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 
      Hebei 050017, P.R. China.
AD  - Tumor Research Institute, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, P.R. China.
FAU - Zhao, Ruili
AU  - Zhao R
AD  - Department of Otolaryngology, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, P.R. China.
FAU - Gu, Lina
AU  - Gu L
AD  - Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 
      Hebei 050017, P.R. China.
FAU - Shan, Baoen
AU  - Shan B
AD  - Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 
      Hebei 050017, P.R. China.
AD  - Tumor Research Institute, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200729
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC7418503
OTO - NOTNLM
OT  - laryngeal squamous cell carcinoma
OT  - melanoma-associated antigen A
OT  - prognosis
OT  - prognostic marker
EDAT- 2020/08/15 06:00
MHDA- 2020/08/15 06:01
PMCR- 2020/07/29
CRDT- 2020/08/15 06:00
PHST- 2019/08/29 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/08/15 06:00 [entrez]
PHST- 2020/08/15 06:00 [pubmed]
PHST- 2020/08/15 06:01 [medline]
PHST- 2020/07/29 00:00 [pmc-release]
AID - OL-0-0-11920 [pii]
AID - 10.3892/ol.2020.11920 [doi]
PST - ppublish
SO  - Oncol Lett. 2020 Oct;20(4):59. doi: 10.3892/ol.2020.11920. Epub 2020 Jul 29.