PMID- 32793587
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 8
DP  - 2020
TI  - LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human 
      Umbilical Vein Endothelial Cells.
PG  - 596
LID - 10.3389/fcell.2020.00596 [doi]
LID - 596
AB  - Porphyromonas gingivalis (P. gingivalis) is one of the main periodontal bacteria. 
      This pathogen was reported to enhance monocyte migration and adhesion to 
      endothelial cells in atherosclerosis. The scavenger receptor lectin-like oxidized 
      low-density lipoprotein receptor-1 (LOX-1) plays a pivotal role in atherogenesis. 
      The aim of this study was to investigate whether LOX-1 modulates P. 
      gingivalis-mediated monocyte migration and adhesion to endothelial cells and how 
      it works. The results showed that the migration and adhesion of monocytic THP-1 
      cells to human umbilical vein endothelial cells (HUVECs) were significantly 
      enhanced when HUVECs or THP-1 cells were challenged with P. gingivalis. 
      Meanwhile, the expression level of LOX-1 in both HUVECs and THP-1 cells were also 
      significantly increased by P. gingivalis stimulation. It is well known that 
      ligand/receptor pairs monocyte chemoattractant protein-1 (MCP-1)/CC chemokine 
      receptor 2 (CCR2), selectins/Integrins, and cell adhesion molecules 
      (CAMs)/Integrins mediate monocyte migration and adhesion to endothelial cells. In 
      this study, LOX-1 was demonstrated to be crucially involved in P. 
      gingivalis-induced THP-1 cell migration and adhesion to HUVECs, by regulating 
      expression of ligands MCP-1, intercellular adhesion molecule-1 (ICAM-1) and 
      E-selectin in HUVECs and that of their receptors CCR2 and Integrin alphaMbeta2 in THP-1 
      cells. The nuclear factor-kappa B (NF-kappaB) signaling pathway was proved to be 
      involved in this process. In conclusion, LOX-1 plays a crucial role in P. 
      gingivalis-induced monocyte migration and adhesion to endothelial cells. This 
      result implies LOX-1 may act as a bridge in linking periodontitis to 
      atherosclerosis.
CI  - Copyright (c) 2020 Li, Liu, Liu, Chu, Zhong, Xie, Lou and Ouyang.
FAU - Li, Qian
AU  - Li Q
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
FAU - Liu, Jianru
AU  - Liu J
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
FAU - Liu, Wenyi
AU  - Liu W
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
FAU - Chu, Yi
AU  - Chu Y
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
AD  - First Clinical Division, Peking University School and Hospital of Stomatology, 
      Beijing, China.
FAU - Zhong, Jinsheng
AU  - Zhong J
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
FAU - Xie, Ying
AU  - Xie Y
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
FAU - Lou, Xinzhe
AU  - Lou X
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
FAU - Ouyang, Xiangying
AU  - Ouyang X
AD  - Department of Periodontology, Peking University School and Hospital of 
      Stomatology, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20200714
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC7394702
OTO - NOTNLM
OT  - HUVECs
OT  - LOX-1
OT  - Porphyromonas gingivalis
OT  - THP-1 cells
OT  - adhesion
OT  - migration
EDAT- 2020/08/15 06:00
MHDA- 2020/08/15 06:01
PMCR- 2020/01/01
CRDT- 2020/08/15 06:00
PHST- 2020/02/06 00:00 [received]
PHST- 2020/06/18 00:00 [accepted]
PHST- 2020/08/15 06:00 [entrez]
PHST- 2020/08/15 06:00 [pubmed]
PHST- 2020/08/15 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2020.00596 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2020 Jul 14;8:596. doi: 10.3389/fcell.2020.00596. 
      eCollection 2020.