PMID- 32793846
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 4
IP  - 9
DP  - 2020 Sep 1
TI  - Interleukin-6 May Not Affect Bone Resorption Marker CTX or Bone Formation Marker 
      P1NP in Humans.
PG  - bvaa093
LID - 10.1210/jendso/bvaa093 [doi]
LID - bvaa093
AB  - CONTEXT: Interleukin 6 (IL-6) contributes to bone remodeling in preclinical 
      studies. Clinical trials investigating the role of IL-6 in bone remodeling are 
      limited. OBJECTIVE: To investigate if IL-6 regulates bone remodeling in humans. 
      DESIGN: Plasma concentrations of the bone resorption marker carboxy-terminal type 
      I collagen crosslinks (CTX) and of the bone formation marker procollagen type 1 
      N-terminal propeptide (P1NP) were measured during a mixed-meal tolerance test 
      (MMTT) in 3 placebo-controlled human studies. PARTICIPANTS: Five healthy 
      individuals participated in study 1; 52 obese individuals, in study 2; and 10 
      healthy individuals, in study 3. INTERVENTIONS: Study 1 was a single-blinded 
      crossover study consisting of a 1-h infusion of saline (placebo) or the IL-6 
      receptor antibody tocilizumab followed by an exercise bout. Study 2 was a 
      randomized, double-blinded 12-week exercise training intervention study. 
      Participants received infusions of saline or tocilizumab. Study 3 was a 
      randomized, double-blinded, crossover study consisting of 30 min infusion of 
      saline or IL-6. MAIN OUTCOMES MEASURES: Effect of IL-6 on CTX levels. RESULTS: 
      CTX was significantly (P < 0.01) decreased during MMTTs in all 3 studies. 
      Treatment with tocilizumab did not affect exercise or meal induced changes in 
      plasma CTX or P1NP concentrations acutely (study 1) or after a 12-week treatment 
      period (study 2). Exogenous IL-6 had no effect on CTX or P1NP plasma 
      concentrations (study 3). CONCLUSIONS: IL-6 may not regulate bone remodeling in 
      humans.
CI  - (c) Endocrine Society 2020.
FAU - Lehrskov, Louise L
AU  - Lehrskov LL
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Kjeldsen, Sasha
AU  - Kjeldsen S
AD  - Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
AD  - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Lyngbaek, Mark P
AU  - Lyngbaek MP
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Chirstensen, Regitse Hojgaard
AU  - Chirstensen RH
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Wedell-Neergaard, Anne-Sophie
AU  - Wedell-Neergaard AS
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Soderlund, Line
AU  - Soderlund L
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Jorgensen, Niklas Rye
AU  - Jorgensen NR
AD  - Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Krogh-Madsen, Rikke
AU  - Krogh-Madsen R
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
FAU - Wewer Albrechtsen, Nicolai J
AU  - Wewer Albrechtsen NJ
AD  - Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
AD  - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Ellingsgaard, Helga
AU  - Ellingsgaard H
AUID- ORCID: 0000-0002-9105-5247
AD  - The Centre of Inflammation and Metabolism and the Centre for Physical Activity 
      Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20200707
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC7414920
OTO - NOTNLM
OT  - bone formation
OT  - bone resorption
OT  - interleukin-6
EDAT- 2020/08/15 06:00
MHDA- 2020/08/15 06:01
PMCR- 2020/07/07
CRDT- 2020/08/15 06:00
PHST- 2020/04/08 00:00 [received]
PHST- 2020/07/03 00:00 [accepted]
PHST- 2020/08/15 06:00 [entrez]
PHST- 2020/08/15 06:00 [pubmed]
PHST- 2020/08/15 06:01 [medline]
PHST- 2020/07/07 00:00 [pmc-release]
AID - bvaa093 [pii]
AID - 10.1210/jendso/bvaa093 [doi]
PST - epublish
SO  - J Endocr Soc. 2020 Jul 7;4(9):bvaa093. doi: 10.1210/jendso/bvaa093. eCollection 
      2020 Sep 1.