PMID- 32794384
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 45
IP  - 3
DP  - 2021 May
TI  - Association between Sleep Quality and Painless Diabetic Peripheral Neuropathy 
      Assessed by Current Perception Threshold in Type 2 Diabetes Mellitus.
PG  - 358-367
LID - 10.4093/dmj.2019.0219 [doi]
AB  - BACKGROUND: It is known that the painful sensation of diabetic peripheral 
      neuropathy (DPN) results in sleep problems in type 2 diabetes mellitus (T2DM). 
      However, it is not known that the painless DPN also is associated with poor sleep 
      quality in T2DM. The purpose of the current study was to investigate the 
      association between painless DPN and poor sleep quality in T2DM. METHODS: A total 
      of 146 patients of T2DM who do not have any painful symptoms of DPN were 
      recruited into the study. Among the patients, painless DPN was diagnosed by using 
      the current perception threshold test. Sleep quality was assessed using the 
      Pittsburgh Sleep Quality Index questionnaire. RESULTS: The percentage of painless 
      DPN was significantly higher in the poor sleep quality group than the good sleep 
      quality group (70.0% vs. 35.5%, P<0.001). In the subscale results, stimulus 
      values at 2,000 Hz, hypoesthesia and hyperesthesia were more common in the poor 
      sleep quality group than in the good sleep quality group (45.7% vs. 25.0%, 
      P=0.009; 34.3% vs. 18.4%, P=0.029; 40.0% vs. 19.7%, P=0.007, respectively). The 
      association of painless DPN and poor sleep quality remained significant after 
      adjustment for significant covariates (odds ratio, 3.825; 95% confidence 
      interval, 1.674 to 8.742; P<0.001). CONCLUSION: The current study showed that 
      painless DPN was associated with poor sleep quality. Future studies are required 
      to clarify the pathophysiologic causal relationship between painless DPN and 
      sleep quality.
FAU - Choi, Dughyun
AU  - Choi D
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
FAU - Kim, Bo-Yeon
AU  - Kim BY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
FAU - Jung, Chan-Hee
AU  - Jung CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
FAU - Kim, Chul-Hee
AU  - Kim CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
FAU - Mok, Ji-Oh
AU  - Mok JO
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of 
      Medicine, Bucheon, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200806
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Diabetic Neuropathies/diagnosis/epidemiology
MH  - Humans
MH  - Pain
MH  - Perception
MH  - Prevalence
MH  - Sleep
PMC - PMC8164947
OTO - NOTNLM
OT  - Diabetes complications
OT  - Diabetes mellitus, type 2
OT  - Diabetic neuropathies
OT  - Sleep
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/08/15 06:00
MHDA- 2023/02/25 06:00
PMCR- 2021/05/01
CRDT- 2020/08/15 06:00
PHST- 2019/11/15 00:00 [received]
PHST- 2020/03/20 00:00 [accepted]
PHST- 2020/08/15 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2020/08/15 06:00 [entrez]
PHST- 2021/05/01 00:00 [pmc-release]
AID - 44.e45 [pii]
AID - dmj-2019-0219 [pii]
AID - 10.4093/dmj.2019.0219 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2021 May;45(3):358-367. doi: 10.4093/dmj.2019.0219. Epub 2020 
      Aug 6.