PMID- 32795368
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20210701
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 17
IP  - 1
DP  - 2020 Aug 14
TI  - Cytomegalovirus and disseminated histoplasmosis-related hemophagocytic 
      lymphohistiocytosis syndrome in an HIV-patient late presenter with IRIS: a case 
      report.
PG  - 52
LID - 10.1186/s12981-020-00304-0 [doi]
LID - 52
AB  - BACKGROUND: Hemophagocytic lymphohistiocytosis syndrome (HLS) is an 
      immune-mediated life-threatening disease considered as a medical emergency, with 
      a potentially fatal multisystem inflammatory outcome. We present a patient that 
      developed HLS and was able to be diagnosed efficiently with the help of an 
      academic research institute of immunology. CASE PRESENTATION: A 21 years old male 
      Mexican with human immunodeficiency virus (HIV), late presenter; who developed 
      cytomegalovirus (CMV) infection and a disseminated histoplasmosis-related HLS, as 
      part of an immune reconstitution inflammatory syndrome (IRIS). The patient 
      required a long course of corticotherapy, intravenous immunoglobulin and massive 
      transfusions (more than 10 units in 24 h, and a total of 83 units), besides 
      amphotericin-B and ganciclovir treatment. An academic research institute of 
      immunology aided in the accurate diagnosis of HLS with the implementation of 
      tests not available within the hospital, thus improving the care provided to the 
      patient. The patient recovered, was discharged, and continue to improve. 
      CONCLUSION: The objective of this report is to highlight the importance of having 
      multidisciplinary support, including basic medical sciences groups providing 
      specific tests that are sometimes very difficult to get, which provides a benefit 
      to patients in the well-aimed diagnosis as part of applied translational 
      medicine.
FAU - Gonzalez-Hernandez, Luz A
AU  - Gonzalez-Hernandez LA
AD  - HIV Unit, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", 
      Guadalajara, Jalisco, Mexico.
AD  - HIV and Immunodeficiencies Research Institute, CUCS-University of Guadalajara, 
      Guadalajara, Jalisco, Mexico.
FAU - Alvarez-Zavala, Monserrat
AU  - Alvarez-Zavala M
AD  - HIV and Immunodeficiencies Research Institute, CUCS-University of Guadalajara, 
      Guadalajara, Jalisco, Mexico.
FAU - Cabrera-Silva, Rodolfo I
AU  - Cabrera-Silva RI
AD  - HIV and Immunodeficiencies Research Institute, CUCS-University of Guadalajara, 
      Guadalajara, Jalisco, Mexico.
FAU - Martinez-Ayala, Pedro
AU  - Martinez-Ayala P
AD  - HIV Unit, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", 
      Guadalajara, Jalisco, Mexico.
FAU - Amador-Lara, Fernando
AU  - Amador-Lara F
AD  - HIV Unit, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", 
      Guadalajara, Jalisco, Mexico.
FAU - Ramirez-Gonzalez, Aida S
AU  - Ramirez-Gonzalez AS
AD  - HIV Unit, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", 
      Guadalajara, Jalisco, Mexico.
FAU - Ron-Magana, Ana L
AU  - Ron-Magana AL
AD  - Hematology and Trasplant Unit, Hospital Civil de Guadalajara "Fray Antonio 
      Alcalde", Guadalajara, Jalisco, Mexico.
FAU - Ruiz Herrera, Vida V
AU  - Ruiz Herrera VV
AD  - HIV Unit, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", 
      Guadalajara, Jalisco, Mexico.
FAU - Sanchez-Reyes, Karina
AU  - Sanchez-Reyes K
AD  - HIV and Immunodeficiencies Research Institute, CUCS-University of Guadalajara, 
      Guadalajara, Jalisco, Mexico. karina_reyesqfb@hotmail.com.
FAU - Andrade-Villanueva, Jaime F
AU  - Andrade-Villanueva JF
AD  - HIV Unit, Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde", 
      Guadalajara, Jalisco, Mexico. drjandradev@gmail.com.
AD  - HIV and Immunodeficiencies Research Institute, CUCS-University of Guadalajara, 
      Guadalajara, Jalisco, Mexico. drjandradev@gmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200814
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
RN  - 0 (Antiviral Agents)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Antiviral Agents/therapeutic use
MH  - Cytomegalovirus Infections/*diagnosis
MH  - HIV Infections/complications/virology
MH  - Histoplasmosis/*blood/complications
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Lymphohistiocytosis, Hemophagocytic/*diagnosis/etiology/therapy
MH  - Male
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC7427876
OTO - NOTNLM
OT  - Applied translational medicine
OT  - Case report
OT  - Cytomegalovirus
OT  - Disseminated histoplasmosis
OT  - HIV
OT  - Hemophagocytic lymphohistiocytosis syndrome
OT  - IRIS
COIS- The authors declare that they have no competing interests.
EDAT- 2020/08/17 06:00
MHDA- 2021/07/02 06:00
PMCR- 2020/08/14
CRDT- 2020/08/16 06:00
PHST- 2020/01/28 00:00 [received]
PHST- 2020/07/22 00:00 [accepted]
PHST- 2020/08/16 06:00 [entrez]
PHST- 2020/08/17 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2020/08/14 00:00 [pmc-release]
AID - 10.1186/s12981-020-00304-0 [pii]
AID - 304 [pii]
AID - 10.1186/s12981-020-00304-0 [doi]
PST - epublish
SO  - AIDS Res Ther. 2020 Aug 14;17(1):52. doi: 10.1186/s12981-020-00304-0.