PMID- 32796432
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20210520
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 71
IP  - 6
DP  - 2020 Dec
TI  - Impaired Bone Health in Children With Biliary Atresia.
PG  - 707-712
LID - 10.1097/MPG.0000000000002896 [doi]
AB  - OBJECTIVES: The aim of the study was to examine the frequency of rickets and bone 
      fractures and to assess areal bone mineral density (aBMD) in childhood among 
      patients with biliary atresia (BA). METHODS: We gathered data on all patients 
      diagnosed with BA in Finland that survived to >/=1 year of age between 1 January 
      2000 to 30 June 2018. Data on gestational age, birth weight, postsurgical 
      medications, and history of rickets and bone fractures were collected 
      retrospectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] 
      postportoenterostomy (PE) were collected. Plain radiographs and dual energy X-ray 
      absorptiometry (DXA) measurements of study subjects were reviewed. RESULTS: Out 
      of 49 patients, 7 (14%) were diagnosed with rickets during infancy. Clearance of 
      jaundice [odds ratio 0.055, 95% confidence interval [CI] 0.00266-0.393; P < 0.01] 
      was a protective factor against rickets. Sufficient 25(OH)D levels were reached 3 
      months post-PE. Eleven (22%) patients suffered at least one bone fracture (range 
      1-9) during childhood and adolescence. In DXA measurements, median lumbar spine 
      aBMD anthropometrically adjusted z-scores were as follows: in native liver 
      survivors 0.8 (interquartile range [IQR] -1.9 to 1.4) at 5 and -0.3 (IQR -1.3 to 
      0.8) at 10 years and for liver transplanted patients 0.4 (IQR -0.2 to 1.1) at 5 
      and 0.6 (IQR -0.1 to 1.3) at 10 years. CONCLUSIONS: BA patients have an increased 
      risk for rickets and bone fractures compared with the normal population. Most BA 
      patients have aBMD within normal range between 5 and 10 years of age irrespective 
      of liver transplantation status.
FAU - Ruuska, Satu
AU  - Ruuska S
AD  - Department of Pediatric Gastroenterology.
AD  - Pediatric Liver and Gut Research Group.
AD  - University of Helsinki.
FAU - Laakso, Saila
AU  - Laakso S
AD  - Pediatric Research Center.
AD  - Department of Pediatrics, Helsinki University Hospital, Helsinki.
AD  - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, 
      University of Helsinki.
FAU - Leskinen, Outi
AU  - Leskinen O
AD  - Department of Pediatric Radiology, HUS Medical Imaging Center, Helsinki 
      University Hospital.
FAU - Hagfors, Anna
AU  - Hagfors A
AD  - City of Helsinki, Social Services and Health Care.
AD  - University of Helsinki.
FAU - Jalanko, Hannu
AU  - Jalanko H
AD  - Pediatric Research Center.
AD  - University of Helsinki.
FAU - Kolho, Kaija-Leena
AU  - Kolho KL
AD  - Pediatric Research Center.
AD  - Department of Pediatrics, Helsinki University Hospital, Helsinki.
AD  - University of Helsinki.
FAU - Pakarinen, Mikko P
AU  - Pakarinen MP
AD  - Pediatric Liver and Gut Research Group.
AD  - Pediatric Research Center.
AD  - University of Helsinki.
AD  - Section of Pediatric Surgery, Helsinki University Hospital, Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - *Biliary Atresia/complications/surgery
MH  - *Bone Density
MH  - Child
MH  - Finland/epidemiology
MH  - Humans
MH  - Infant
MH  - Retrospective Studies
EDAT- 2020/08/17 06:00
MHDA- 2021/05/21 06:00
CRDT- 2020/08/16 06:00
PHST- 2020/08/17 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2020/08/16 06:00 [entrez]
AID - 00005176-202012000-00005 [pii]
AID - 10.1097/MPG.0000000000002896 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2020 Dec;71(6):707-712. doi: 
      10.1097/MPG.0000000000002896.