PMID- 32798003
OWN - NLM
STAT- MEDLINE
DCOM- 20201001
LR  - 20210110
IS  - 1879-291X (Electronic)
IS  - 0301-5629 (Print)
IS  - 0301-5629 (Linking)
VI  - 46
IP  - 11
DP  - 2020 Nov
TI  - Lung Ultrasound Findings Are Associated with Mortality and Need for Intensive 
      Care Admission in COVID-19 Patients Evaluated in the Emergency Department.
PG  - 2927-2937
LID - S0301-5629(20)30302-1 [pii]
LID - 10.1016/j.ultrasmedbio.2020.07.005 [doi]
AB  - Lung ultrasound (LUS) has recently been advocated as an accurate tool to diagnose 
      coronavirus disease 2019 (COVID-19) pneumonia. However, reports on its use are 
      based mainly on hypothesis studies, case reports or small retrospective case 
      series, while the prognostic role of LUS in COVID-19 patients has not yet been 
      established. We conducted a prospective study aimed at assessing the ability of 
      LUS to predict mortality and intensive care unit admission of COVID-19 patients 
      evaluated in a tertiary level emergency department. Patients in our sample had a 
      median of 6 lung areas with pathologic findings (inter-quartile range [IQR]: 6, 
      range: 0-14), defined as a score different from 0. The median rate of lung areas 
      involved was 71% (IQR: 64%, range: 0-100), while the median average score was 
      1.14 (IQR: 0.93, range: 0-3). A higher rate of pathologic lung areas and a higher 
      average score were significantly associated with death, with an estimated 
      difference of 40.5% (95% confidence interval [CI]: 4%-68%, p = 0.01) and of 0.47 
      (95% CI: 0.06-0.93, p = 0.02), respectively. Similarly, the same parameters were 
      associated with a significantly higher risk of intensive care unit admission with 
      estimated differences of 29% (95% CI: 8%-50%, p = 0.008) and 0.47 (95% CI: 
      0.05-0.93, p = 0.02), respectively. Our study indicates that LUS is able to 
      detect COVID-19 pneumonia and to predict, during the first evaluation in the 
      emergency department, patients at risk for intensive care unit admission and 
      death.
CI  - Copyright (c) 2020 World Federation for Ultrasound in Medicine & Biology. Published 
      by Elsevier Inc. All rights reserved.
FAU - Bonadia, Nicola
AU  - Bonadia N
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy. Electronic address: nicola.bonadia@policlinicogemelli.it.
FAU - Carnicelli, Annamaria
AU  - Carnicelli A
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Piano, Alfonso
AU  - Piano A
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Buonsenso, Danilo
AU  - Buonsenso D
AD  - Department of Woman and Child Health and Public Health, Fondazione Policlinico 
      Universitario A. Gemelli IRCCS, Rome, Italy; Istituto di Microbiologia, 
      Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Gilardi, Emanuele
AU  - Gilardi E
AD  - Emergency Department, Campus Bio-Medico University of Rome, Rome, Italy.
FAU - Kadhim, Cristina
AU  - Kadhim C
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Torelli, Enrico
AU  - Torelli E
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Petrucci, Martina
AU  - Petrucci M
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Di Maurizio, Luca
AU  - Di Maurizio L
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Biasucci, Daniele Guerino
AU  - Biasucci DG
AD  - Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario 
      A. Gemelli IRCCS, Rome, Italy.
FAU - Fuorlo, Mariella
AU  - Fuorlo M
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Forte, Evelina
AU  - Forte E
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Zaccaria, Raffaella
AU  - Zaccaria R
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy.
FAU - Franceschi, Francesco
AU  - Franceschi F
AD  - Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Rome, Italy; School of Emergency Medicine, Catholic University of Sacred 
      Heart, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200715
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - Betacoronavirus
MH  - COVID-19
MH  - COVID-19 Testing
MH  - Clinical Laboratory Techniques
MH  - Coronavirus Infections/diagnosis/*diagnostic imaging/*mortality
MH  - Emergency Service, Hospital/*organization & administration
MH  - Female
MH  - Humans
MH  - *Intensive Care Units
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Pandemics
MH  - Patient Admission
MH  - Pneumonia, Viral/*diagnostic imaging/*mortality/virology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - SARS-CoV-2
MH  - Ultrasonography/*methods
PMC - PMC7362856
OTO - NOTNLM
OT  - COVID-19
OT  - Emergency medicine
OT  - Lung ultrasound
OT  - Pneumonia
OT  - SARS-CoV-2
EDAT- 2020/08/17 06:00
MHDA- 2020/10/02 06:00
PMCR- 2020/07/15
CRDT- 2020/08/17 06:00
PHST- 2020/05/22 00:00 [received]
PHST- 2020/06/17 00:00 [revised]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/08/17 06:00 [pubmed]
PHST- 2020/10/02 06:00 [medline]
PHST- 2020/08/17 06:00 [entrez]
PHST- 2020/07/15 00:00 [pmc-release]
AID - S0301-5629(20)30302-1 [pii]
AID - 10.1016/j.ultrasmedbio.2020.07.005 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2020 Nov;46(11):2927-2937. doi: 
      10.1016/j.ultrasmedbio.2020.07.005. Epub 2020 Jul 15.