PMID- 32799030 OWN - NLM STAT- MEDLINE DCOM- 20210621 LR - 20210621 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 73 DP - 2020 Sep TI - Health-related quality of life and sleep quality among North Indian type 2 diabetes mellitus patients: evidence from a cross-sectional study. PG - 93-100 LID - S1389-9457(20)30193-3 [pii] LID - 10.1016/j.sleep.2020.04.022 [doi] AB - OBJECTIVE: The objective of this study is to measure the relationship between sleep quality and health-related quality of life (HRQOL), in Indian population with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study, included a total of 300 patients with T2DM. All participants were responding to the Pittsburgh Sleep Quality Index (PSQI) and European Quality of Life-5 Dimensions Questionnaire (EQ-5D). A PSQI global score >/=5 was defined as poor sleep quality. EQ-5D visual analogue scale (VAS), determining the overall health status. Logistic regression analysis was used to examine the association between PSQI and EQ-5D. All the study data were analysed using the SPSS software version 20.0. Values of p < 0.05 were considered statistically significant. RESULTS: The mean age of included participants were 55.29. Majority of the participants (55.3%) were identified as "poor sleepers" and female (31.3%) contributing higher proportion. Poor sleepers had significantly lower the HRQoL (p < 0.001). After adjustment, poor sleep quality was significantly associated with a lower HRQoL; EQ-5D index (OR = 1.080, 95%, CI: 1.015-1.148, p < 0.05), and EQ-5D VAS (OR = 1.092, 95%, CI: 1.021-1.176, p < 0.01). Overall, the EQ-5D index and EQ-5D VAS were found to be an independent predictors of sleep quality. CONCLUSIONS: Poor sleep quality is prevalent in Indian T2DM population, and it imparts negative impact on several dimensions of EQ-5D that characterising the daily activities performance. Therefore, further real-world studies are needed to determine the causal relationship between T2DM patients and measure of objective sleep and their impact on health. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Azharuddin, Md AU - Azharuddin M AD - Department of Pharmaceutical Medicine, Division of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. FAU - Kapur, Prem AU - Kapur P AD - Department of Medicine, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address: kapurprem@yahoo.com. FAU - Adil, Mohammad AU - Adil M AD - Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. FAU - Ghosh, Pinaki AU - Ghosh P AD - Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth, Pune, 411038, India. FAU - Sharma, Manju AU - Sharma M AD - Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address: msharma@jamiahamdard.ac.in. LA - eng PT - Journal Article DEP - 20200505 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Female MH - Health Status MH - Humans MH - *Quality of Life MH - Sleep MH - Surveys and Questionnaires OTO - NOTNLM OT - European quality of Life-5 dimensions questionnaire OT - Health-related quality of life OT - Pittsburgh sleep quality index OT - Sleep quality OT - Type 2 diabetes mellitus OT - Visual analogue scale EDAT- 2020/08/18 06:00 MHDA- 2021/06/22 06:00 CRDT- 2020/08/18 06:00 PHST- 2020/02/23 00:00 [received] PHST- 2020/04/12 00:00 [revised] PHST- 2020/04/23 00:00 [accepted] PHST- 2020/08/18 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/08/18 06:00 [entrez] AID - S1389-9457(20)30193-3 [pii] AID - 10.1016/j.sleep.2020.04.022 [doi] PST - ppublish SO - Sleep Med. 2020 Sep;73:93-100. doi: 10.1016/j.sleep.2020.04.022. Epub 2020 May 5.