PMID- 32799431
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 73
IP  - 11
DP  - 2021 Nov
TI  - Systematic Review of the Evolution of Health-Economic Evaluation Models of 
      Osteoarthritis.
PG  - 1617-1627
LID - 10.1002/acr.24410 [doi]
AB  - OBJECTIVE: To comprehensively synthesize the evolution of health-economic 
      evaluation models (HEEMs) of all osteoarthritis (OA) interventions, including 
      preventions, core treatments, adjunct nonpharmacologic interventions, 
      pharmacologic interventions, and surgical treatments. METHODS: The literature was 
      searched within health-economic/biomedical databases. Data extracted included OA 
      type, population characteristics, model setting/type/events, study perspective, 
      and comparators; the reporting quality of the studies was also assessed. The 
      review protocol was registered at the International Prospective Register of 
      Systematic Reviews (CRD42018092937). RESULTS: Eighty-eight studies were included. 
      Pharmacologic and surgical interventions were the focus in 51% and 44% of 
      studies, respectively. Twenty-four studies adopted a societal perspective (with 
      increasing popularity after 2013), but most (63%) did not include indirect costs. 
      Quality-adjusted life years was the most popular outcome measure since 2008. 
      Markov models were used by 62% of studies, with increasing popularity since 2008. 
      Until 2010, most studies used short-to-medium time horizons; subsequently, a 
      lifetime horizon became popular. A total of 86% of studies reported discount 
      rates (predominantly between 3% and 5%). Studies published after 2002 had a 
      better coverage of OA-related adverse events (AEs). Reporting quality 
      significantly improved after 2001. CONCLUSION: OA HEEMs have evolved and improved 
      substantially over time, with the focus shifting from short-to-medium-term 
      pharmacologic decision-tree models to surgical-focused lifetime Markov models. 
      Indirect costs of OA are frequently not considered, despite using a societal 
      perspective. There was a lack of reporting sensitivity of model outcome to input 
      parameters, including discount rate, OA definition, and population parameters. 
      While the coverage of OA-related AEs has improved over time, it is still not 
      comprehensive.
CI  - (c) 2020, American College of Rheumatology.
FAU - Zhao, Ting
AU  - Zhao T
AUID- ORCID: 0000-0002-2145-1930
AD  - University of Tasmania, Hobart, Tasmania, Australia.
FAU - Ahmad, Hasnat
AU  - Ahmad H
AD  - University of Tasmania, Hobart, Tasmania, Australia.
FAU - de Graaff, Barbara
AU  - de Graaff B
AD  - University of Tasmania, Hobart, Tasmania, Australia.
FAU - Xia, Qing
AU  - Xia Q
AD  - University of Tasmania, Hobart, Tasmania, Australia.
FAU - Winzenberg, Tania
AU  - Winzenberg T
AD  - University of Tasmania, Hobart, Tasmania, Australia.
FAU - Aitken, Dawn
AU  - Aitken D
AUID- ORCID: 0000-0001-5685-7634
AD  - University of Tasmania, Hobart, Tasmania, Australia.
FAU - Palmer, Andrew J
AU  - Palmer AJ
AD  - University of Tasmania, Hobart, Tasmania, and The University of Melbourne, 
      Parkville, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20210924
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Decision Support Techniques
MH  - Decision Trees
MH  - *Health Care Costs
MH  - Humans
MH  - Markov Chains
MH  - *Models, Economic
MH  - Osteoarthritis/diagnosis/*economics/*therapy
MH  - Outcome and Process Assessment, Health Care/*economics
MH  - Quality of Life
MH  - Quality-Adjusted Life Years
MH  - Rheumatology/*economics
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2020/08/18 06:00
MHDA- 2021/11/16 06:00
CRDT- 2020/08/18 06:00
PHST- 2019/11/17 00:00 [received]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2020/08/18 06:00 [entrez]
AID - 10.1002/acr.24410 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2021 Nov;73(11):1617-1627. doi: 10.1002/acr.24410. 
      Epub 2021 Sep 24.