PMID- 32799861 OWN - NLM STAT- MEDLINE DCOM- 20210618 LR - 20210618 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 19 IP - 1 DP - 2020 Aug 14 TI - Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis. PG - 184 LID - 10.1186/s12944-020-01360-1 [doi] LID - 184 AB - BACKGROUND: To investigate whether atherogenic index of plasma (AIP) at diagnosis is associated with the occurrence of cerebrovascular accident (CVA) or coronary artery disease (CAD) in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: The medical records of 167 AAV patients on initial diagnosis was reviewed, and 300 healthy controls were included. AIP was calculated using the following equation: AIP = Log (triglyceride [mg/dL] / high-density lipoprotein cholesterol [mg/dL]). AAV patients were divided into two groups according to the AIP cut-off of 0.11. The event of stroke, transient ischemic attack, and cerebral hemorrhage was recorded as CVA, and CAD events consisted of either myocardial infarction and angina pectoris. CVA- and CAD- free survival rate between those with AIP >/= 0.11 and < 0.11 were compared by the Kaplan-Meier analysis, and Cox hazard analysis was conducted to identify predictors of CVA. RESULTS: The median age of AAV patients were 59.0 years, and 54 (32.3%) patients were male. One-hundred and fifteen (68.9%) patients had AIP < 0.11 and 52 (31.1%) had AIP >/= 0.11. The mean Birmingham vasculitis activity score in AAV patients with AIP < 0.11 was lower than that seen in patients with AIP >/= 0.11 (12.0 vs. 14.0, P = 0.041). AAV patients had a significantly higher AIP compared to controls (mean - 0.01 vs. -0.10, P < 0.001). During follow-up, the occurrence of CVA and CAD was observed in 16 (9.6%) and 14 (8.4%) patients, respectively. In Kaplan-Meier analysis, AAV patients with AIP >/= 0.11 had significantly lower CVA-free survival rates than in those with AIP < 0.11 (P = 0.027), whereas there was no difference in CAD according to AIP (P = 0.390). Multivariable Cox analysis indicated that AIP >/= 0.11 at diagnosis was the sole predictor of CVA (Hazard ratio 3.392, 95% confidence interval 1.076, 10.696, P = 0.037). CONCLUSIONS: AIP is significantly higher in AAV patients than in healthy controls, and AIP >/= 0.11 at diagnosis is a significant predictor of CVA during follow-up. Stringent surveillance should be provided in AAV patients with AIP >/= 0.11 regarding the occurrence of CVA. TRIAL REGISTRATION: Retrospectively registered (4-2017-0673). FAU - Ahn, Sung Soo AU - Ahn SS AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 03722. FAU - Lee, Lucy Eunju AU - Lee LE AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 03722. FAU - Pyo, Jung Yoon AU - Pyo JY AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 03722. FAU - Song, Jason Jungsik AU - Song JJ AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 03722. AD - Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Park, Yong-Beom AU - Park YB AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 03722. AD - Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Sang-Won AU - Lee SW AUID- ORCID: 0000-0002-8038-3341 AD - Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea, 03722. sangwonlee@yuhs.ac. AD - Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea. sangwonlee@yuhs.ac. LA - eng GR - NRF-2018R1A5A2025079/National Research Foundation of Korea/ PT - Journal Article DEP - 20200814 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 RN - 0 (Biomarkers) RN - 0 (Cholesterol, HDL) RN - 0 (Triglycerides) SB - IM MH - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*blood/complications/*mortality MH - Atherosclerosis/*blood MH - Biomarkers/blood MH - Body Mass Index MH - Case-Control Studies MH - Cholesterol, HDL/blood MH - Coronary Artery Disease/blood MH - Female MH - Humans MH - Male MH - Middle Aged MH - Retrospective Studies MH - Risk Factors MH - Stroke/*blood/drug therapy/mortality MH - Triglycerides/blood PMC - PMC7429760 OTO - NOTNLM OT - Antineutrophil cytoplasmic antibody OT - Atherogenic index of plasma OT - Cerebrovascular accident OT - Predictor OT - Vasculitis COIS- The authors declare that they have no competing interests. EDAT- 2020/08/18 06:00 MHDA- 2021/06/22 06:00 PMCR- 2020/08/14 CRDT- 2020/08/18 06:00 PHST- 2020/05/26 00:00 [received] PHST- 2020/08/05 00:00 [accepted] PHST- 2020/08/18 06:00 [entrez] PHST- 2020/08/18 06:00 [pubmed] PHST- 2021/06/22 06:00 [medline] PHST- 2020/08/14 00:00 [pmc-release] AID - 10.1186/s12944-020-01360-1 [pii] AID - 1360 [pii] AID - 10.1186/s12944-020-01360-1 [doi] PST - epublish SO - Lipids Health Dis. 2020 Aug 14;19(1):184. doi: 10.1186/s12944-020-01360-1.