PMID- 32799948
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20240226
IS  - 2040-1752 (Electronic)
IS  - 2040-1744 (Linking)
VI  - 12
IP  - 3
DP  - 2021 Jun
TI  - Intrauterine growth restriction predisposes to airway inflammation without 
      disruption of epithelial integrity in postnatal male mice.
PG  - 496-504
LID - 10.1017/S2040174420000744 [doi]
AB  - Evidence from animal models demonstrate that intrauterine growth restriction 
      (IUGR) alters airway structure and function which may affect susceptibility to 
      disease. Airway inflammation and dysregulated epithelial barrier properties are 
      features of asthma which have not been examined in the context of IUGR. This 
      study used a maternal hypoxia-induced IUGR mouse model to assess lung-specific 
      and systemic inflammation and airway epithelial tight junctions (TJs) protein 
      expression. Pregnant BALB/c mice were housed under hypoxic conditions (10.5% O2) 
      from gestational day (GD) 11 to 17.5 (IUGR group; term, GD 21). Following hypoxic 
      exposure, mice were returned to a normoxic environment (21% O2). A Control group 
      was housed under normoxic conditions throughout pregnancy. Offspring weights were 
      recorded at 2 and 8 weeks of age and euthanized for bronchoalveolar lavage (BAL) 
      and peritoneal cavity fluid collection for inflammatory cells counts. From a 
      separate group of mice, right lungs were collected for Western blotting of TJs 
      proteins. IUGR offspring had greater inflammatory cells in the BAL fluid but not 
      in peritoneal fluid compared with Controls. At 8 weeks of age, interleukin 
      (IL)-2, IL-13, and eotaxin concentrations were higher in male IUGR compared with 
      male Control offspring but not in females. IUGR had no effect on TJs protein 
      expression. Maternal hypoxia-induced IUGR increases inflammatory cells in the BAL 
      fluid of IUGR offspring with no difference in TJs protein expression. Increased 
      cytokine release, specific to the lungs of IUGR male offspring, indicates that 
      both IUGR and sex can influence susceptibility to airway disease.
FAU - Looi, Kevin
AU  - Looi K
AUID- ORCID: 0000-0003-4241-2321
AD  - Telethon Kids Institute, The University of Western Australia, Crawley, WA6009, 
      Australia.
AD  - School of Public Health, Curtin University, Bentley, WA6102, Australia.
FAU - Kicic, Anthony
AU  - Kicic A
AUID- ORCID: 0000-0002-0008-9733
AD  - Telethon Kids Institute, The University of Western Australia, Crawley, WA6009, 
      Australia.
AD  - School of Public Health, Curtin University, Bentley, WA6102, Australia.
AD  - Faculty of Health and Medical Science, The University of Western Australia, 
      Crawley, WA6009, Australia.
AD  - Department of Respiratory and Sleep Medicine, Perth Children's Hospital, 
      Nedlands, WA6009, Australia.
AD  - Centre for Cell Therapy and Regenerative Medicine, The University of Western 
      Australia, Crawley, WA6009, Australia.
FAU - Noble, Peter B
AU  - Noble PB
AUID- ORCID: 0000-0001-9028-7751
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA6009, 
      Australia.
FAU - Wang, Kimberley C W
AU  - Wang KCW
AUID- ORCID: 0000-0002-8604-5909
AD  - Telethon Kids Institute, The University of Western Australia, Crawley, WA6009, 
      Australia.
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA6009, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200817
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
RN  - 0 (Cytokines)
RN  - 0 (Tight Junction Proteins)
SB  - IM
MH  - Animals
MH  - Asthma/*etiology/metabolism
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Cytokines/analysis/metabolism
MH  - Disease Susceptibility
MH  - Epithelium/*metabolism
MH  - Female
MH  - *Fetal Growth Retardation
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Pregnancy
MH  - Sex Factors
MH  - Tight Junction Proteins/*metabolism
MH  - Mice
OTO - NOTNLM
OT  - IUGR
OT  - airway epithelium
OT  - airway inflammation
OT  - tight junctions
EDAT- 2020/08/18 06:00
MHDA- 2022/01/27 06:00
CRDT- 2020/08/18 06:00
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2020/08/18 06:00 [entrez]
AID - S2040174420000744 [pii]
AID - 10.1017/S2040174420000744 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2021 Jun;12(3):496-504. doi: 10.1017/S2040174420000744. 
      Epub 2020 Aug 17.