PMID- 32800240
OWN - NLM
STAT- MEDLINE
DCOM- 20200828
LR  - 20200828
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 202
DP  - 2020 Oct 1
TI  - Comprehensive assessment of unutilized and obsolete pesticides impact on genetic 
      status and health of population of Almaty region.
PG  - 110905
LID - S0147-6513(20)30744-2 [pii]
LID - 10.1016/j.ecoenv.2020.110905 [doi]
AB  - The group of persistent organic pollutants (POPs) are particularly dangerous for 
      the environment and by consequence for human health because of the risk to be 
      transmitted in the food chain. Among them, the urgent problem of obsolete and 
      forbidden organochlorinated pesticides (OCPs) needs a rigorous management in many 
      countries, including Kazakhstan. The aim of our study was to evaluate the effect 
      of pesticides content in food products on the genetic status and health of the 
      population living on the contaminated areas near destroyed warehouses for OCPs (4 
      villages of Talgar district and 1 control site, Almaty region). The food products 
      sampled in Taukaraturyk (control site), and in 4 villages where non-utilized 
      obsolete pesticides were discovered: Beskainar, Kyzylkairat, Amangeldy, and 
      Belbulak. The contents of 24 pesticides in food products from plant (apples, 
      pears, tomatoes, cucumbers, sweet peppers) and animal (beef meat, cow milk, 
      honey) origin, that grown in places of localization of non-utilized OCPs, were 
      determined, sometimes in high and unacceptably high concentrations (before 2500 
      times over MRL). In pears, the pesticides content (especially DDT, gamma-HCH, beta-HCH, 
      endosulfan, and aldrin pesticide group), was higher than in other fruits. Among 
      vegetables, the highest levels of all groups of pesticide were found in 
      cucumbers. Beef meat samples demonstrated increased contents of beta-HCH, gamma-HCH, 
      endrin and dieldrin. In cow milk samples only the high concentration of dieldrin 
      was found. The content of pesticides in meat was 4-5 times higher than in milk. 
      The medical examinations, carried out among the cohorts living around the 
      polluted by pesticides territories and control cohort from ecologically favorable 
      village, showed that there were more individuals with high and middle levels of 
      somatic health in the control group than in groups exposed to OCPs. The long-term 
      effect of the pesticide contamination of the environment on genetic status of the 
      population was assessed by chromosomal aberration (CA) frequencies. The highest 
      level of chromosomal aberrations was identified for the examined residents of 
      Kyzylkairat (41%) and Belbulak (38%), a high level in Amangeldy (12%), and middle 
      level in Beskainar (6.5%). The association between the CA frequency, health 
      status and the pesticides contents in food were assessed by a Spearman rank 
      correlation. The low indicators of somatic health status were strictly associated 
      with high levels of CA, and good health status indicates that the CA rates did 
      not exceed the spontaneous level of mutagenesis. The strongest correlation was 
      shown between high levels of chromosomal aberrations and the content of different 
      pesticides in pears (Cr = 0.979-0.467), tomatoes (Cr = 0.877-0.476), cucumbers 
      (Cr = 0.975-0.553) and meat (Cr = 0.839-0.368). The obtained results highlight 
      the need to improve health protection by increasing the public awareness to the 
      security of the storage of obsolete OCPs in order to strengthen food safety by 
      efficient control services.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Djangalina, Erika
AU  - Djangalina E
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan; 
      Al-Farabi Kazakh National University, 71 Al-Farabi St., Almaty, Kazakhstan. 
      Electronic address: djangalina@rambler.ru.
FAU - Altynova, Nazym
AU  - Altynova N
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan. 
      Electronic address: naz10.79@mail.ru.
FAU - Bakhtiyarova, Sholpan
AU  - Bakhtiyarova S
AD  - Institute of Human and Animal Physiology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Kapysheva, Unzira
AU  - Kapysheva U
AD  - Institute of Human and Animal Physiology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Zhaksymov, Bolat
AU  - Zhaksymov B
AD  - Institute of Human and Animal Physiology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Shadenova, Elvira
AU  - Shadenova E
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Baizhanov, Mukhtar
AU  - Baizhanov M
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Sapargali, Oraz
AU  - Sapargali O
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Garshin, Alexander
AU  - Garshin A
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan; 
      Al-Farabi Kazakh National University, 71 Al-Farabi St., Almaty, Kazakhstan.
FAU - Seisenbayeva, Akerke
AU  - Seisenbayeva A
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Delannoy, Matthieu
AU  - Delannoy M
AD  - Universite de Loraine, Inrae, URAFPA, 2 Avenue de La Foret-de-Haye, Nancy, 
      France.
FAU - Jurjanz, Stefan
AU  - Jurjanz S
AD  - Universite de Loraine, Inrae, URAFPA, 2 Avenue de La Foret-de-Haye, Nancy, 
      France.
FAU - Khussainova, Elmira
AU  - Khussainova E
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan.
FAU - Bekmanov, Bakhytzhan
AU  - Bekmanov B
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan; 
      Al-Farabi Kazakh National University, 71 Al-Farabi St., Almaty, Kazakhstan.
FAU - Djansugurova, Leyla
AU  - Djansugurova L
AD  - Institute of General Genetics and Cytology, 93 Al-Farabi St., Almaty, Kazakhstan; 
      Al-Farabi Kazakh National University, 71 Al-Farabi St., Almaty, Kazakhstan.
LA  - eng
PT  - Journal Article
DEP - 20200704
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - I0246D2ZS0 (Dieldrin)
RN  - OKA6A6ZD4K (Endosulfan)
RN  - OZE3CLY605 (Aldrin)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Aldrin/analysis
MH  - Animals
MH  - Cattle
MH  - Dieldrin/analysis
MH  - Endosulfan/analysis
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Monitoring/methods
MH  - Environmental Pollutants/*analysis
MH  - Environmental Pollution
MH  - Hexachlorocyclohexane
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis
MH  - Pesticides/*analysis
OTO - NOTNLM
OT  - Food products
OT  - Genetic status
OT  - OCPs
OT  - Rank correlation
OT  - Somatic health
EDAT- 2020/08/18 06:00
MHDA- 2020/08/29 06:00
CRDT- 2020/08/18 06:00
PHST- 2020/03/11 00:00 [received]
PHST- 2020/06/12 00:00 [revised]
PHST- 2020/06/15 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2020/08/29 06:00 [medline]
AID - S0147-6513(20)30744-2 [pii]
AID - 10.1016/j.ecoenv.2020.110905 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2020 Oct 1;202:110905. doi: 10.1016/j.ecoenv.2020.110905. 
      Epub 2020 Jul 4.