PMID- 32801451
OWN - NLM
STAT- MEDLINE
DCOM- 20210518
LR  - 20240329
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 84
IP  - 3
DP  - 2020 Jul
TI  - A modified-live porcine reproductive and respiratory syndrome virus (PRRSV) 
      vaccine protects late-term pregnancy gilts against a heterologous PRRSV-2 
      challenge.
PG  - 172-180
AB  - The objective of this study was to evaluate the efficacy of a modified-live virus 
      (MLV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine against 
      a heterologous PRRSV-2 challenge in late-term pregnancy gilts under experimental 
      conditions. Eighteen gilts were randomly assigned to vaccinated-challenged, 
      unvaccinated-challenged, and unvaccinated-unchallenged groups (n = 6 gilts per 
      group). Pregnant gilts in the vaccinated-challenged and unvaccinated-unchallenged 
      groups were able to carry their pregnancies to full term and farrowed after 114 
      to 115 days of gestation. In contrast, pregnant gilts in the 
      unvaccinated-challenged group did not reach full term and farrowed early, after 
      104 to 108 days of gestation. Pregnant gilts vaccinated with the PRRSV-2 MLV 
      vaccine exhibited a reduction in PRRSV-2 viremia. At the time of challenge with 
      PRRSV-2, vaccinated gilts had relatively low levels of neutralizing antibody 
      titers (</= 1:16 titer), whereas the number of interferon-gamma-secreting cells 
      (IFN-gamma-SC) was consistently at protective levels (IFN-gamma-SC, >/= 150 per million). 
      Induction of cell-mediated immunity, as measured by PRRSV-2-specific IFN-gamma-SC, 
      correlated with a reduction in PRRSV-2 viremia. Duration of immunity was a 
      minimum of 19 wk. Taken together, the results presented here suggest that 
      vaccination of gilts with a PRRSV-2 MLV vaccine can protect against a 
      heterologous PRRSV-2 challenge and improve the reproductive performance of 
      late-term pregnancy gilts.
CI  - Copyright and/or publishing rights held by the Canadian Veterinary Medical 
      Association.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Cho, Hyejean
AU  - Cho H
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Min, Kyung-Duk
AU  - Min KD
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, (Yang, Cho, 
      Oh, Park, Kang, Chae) and Institute of Health and Environment (Min), Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Female
MH  - Porcine Reproductive and Respiratory Syndrome/blood/*prevention & 
      control/virology
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/prevention & control/veterinary/virology
MH  - RNA, Viral/blood
MH  - Swine
MH  - Viral Vaccines/*immunology
PMC - PMC7301676
EDAT- 2020/08/18 06:00
MHDA- 2021/05/19 06:00
PMCR- 2021/01/01
CRDT- 2020/08/18 06:00
PHST- 2019/01/27 00:00 [received]
PHST- 2019/08/27 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2021/05/19 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - cjvr_03_172 [pii]
PST - ppublish
SO  - Can J Vet Res. 2020 Jul;84(3):172-180.