PMID- 32801742
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1178-6930 (Print)
IS  - 1178-6930 (Electronic)
IS  - 1178-6930 (Linking)
VI  - 13
DP  - 2020
TI  - Up-Regulation of Tiam1 Promotes the Radioresistance of Laryngeal Squamous Cell 
      Carcinoma Through Activation of the JNK/ATF-2 Signaling Pathway.
PG  - 7065-7074
LID - 10.2147/OTT.S257748 [doi]
AB  - PURPOSE: Our previous study has revealed that T-lymphoma invasion and 
      metastasis-inducing factor 1 (Tiam1) overexpression are significantly associated 
      with aggressive behavior and poor prognosis in patients with laryngeal squamous 
      cell carcinoma (LSCC). However, the influence of Tiam1 in the radioresistance of 
      LSCC and its mechanism have never been elucidated. MATERIALS AND METHODS: Western 
      blotting was used to confirm the relationship between Tiam1 and the JNK/ATF-2 
      signaling pathway. To explore the specific functions of Tiam1 and JNK/ATF-2 
      signaling pathway on the proliferation and apoptosis of LSCC after radiation, 
      cloning formation assay and flow cytometry were conducted in vitro, and the 
      experiments on a xenograft mouse model and TUNEL assay were performed in vivo. 
      RESULTS: Western blotting indicated that Tiam1 can regulate the JNK/ATF-2 
      signaling pathway through the influence of the activity of JNK and ATF-2. 
      Up-regulation of Tiam1 could promote proliferation and inhibit apoptosis of LSCC 
      after radiation both in vitro and in vivo. Moreover, the down-regulation of the 
      JNK/ATF-2 signaling pathway reduced the radioresistance of LSCC caused by Tiam1 
      up-regulation. CONCLUSION: These results suggest that the up-regulation of Tiam1 
      expression can promote the radioresistance of LSCC through activation of the 
      JNK/ATF-2 signaling pathway.
CI  - (c) 2020 Wang et al.
FAU - Wang, Shuang
AU  - Wang S
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Zhu, Weiyu
AU  - Zhu W
AD  - Department of Head and Neck Surgery, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, Shenzhen 518116, Guangdong, 
      People's Republic of China.
FAU - Ouyang, Lei
AU  - Ouyang L
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Li, Jingkun
AU  - Li J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Li, Shisheng
AU  - Li S
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
FAU - Yang, Xinming
AU  - Yang X
AD  - Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200721
PL  - New Zealand
TA  - Onco Targets Ther
JT  - OncoTargets and therapy
JID - 101514322
PMC - PMC7382609
OTO - NOTNLM
OT  - JNK/ATF-2 signaling pathway
OT  - Tiam1
OT  - laryngeal squamous cell carcinoma
OT  - radioresistance
OT  - up-regulation
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/08/18 06:00
MHDA- 2020/08/18 06:01
PMCR- 2020/07/21
CRDT- 2020/08/18 06:00
PHST- 2020/04/10 00:00 [received]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2020/08/18 06:01 [medline]
PHST- 2020/07/21 00:00 [pmc-release]
AID - 257748 [pii]
AID - 10.2147/OTT.S257748 [doi]
PST - epublish
SO  - Onco Targets Ther. 2020 Jul 21;13:7065-7074. doi: 10.2147/OTT.S257748. 
      eCollection 2020.