PMID- 32802825
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2312-0541 (Print)
IS  - 2312-0541 (Electronic)
IS  - 2312-0541 (Linking)
VI  - 6
IP  - 3
DP  - 2020 Jul
TI  - The opposite effect of human leukocyte antigen genotypes in sarcoidosis and 
      tuberculosis: a narrative review of the literature.
LID - 00155-2020 [pii]
LID - 10.1183/23120541.00155-2020 [doi]
AB  - Sarcoidosis and tuberculosis share several similar clinical and pathogenic 
      characteristics that make some researchers consider a common pathogenesis for 
      these diseases. Human leukocyte antigen (HLA) genotypes are studied both in 
      sarcoidosis and tuberculosis patients, but to our knowledge, there are no 
      comparative studies of genetic predisposition for sarcoidosis and tuberculosis 
      development. The aim of this review was to analyse the relationship between HLA 
      genotypes and the development of sarcoidosis and tuberculosis. Original and 
      review articles published in various online databases from 1960 to 2019 were 
      studied. The search results showed opposite effects of the HLA genotypes on 
      predisposition to sarcoidosis or tuberculosis. It was revealed that the genotypes 
      predisposing to the development of sarcoidosis (HLA-DRB1*03/07/15) have 
      protective properties against the development of tuberculosis. Moreover, 
      genotypes causing the development of tuberculosis (HLA-DRB1*04) have a protective 
      effect on the development of sarcoidosis. The results of this narrative review of 
      the literature may allude to the existence of genetic predispositions that lead 
      to the development of an antibacterial or autoimmune response to mycobacteria.
CI  - Copyright (c)ERS 2020.
FAU - Malkova, Anna
AU  - Malkova A
AD  - Saint Petersburg State University, Saint Petersburg, Russia.
FAU - Starshinova, Anna
AU  - Starshinova A
AUID- ORCID: 0000-0002-9023-6986
AD  - Almazov National Medical Research Centre, Saint Petersburg, Russia.
FAU - Zinchenko, Yulia
AU  - Zinchenko Y
AD  - Saint Petersburg State University, Saint Petersburg, Russia.
AD  - Saint Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg, 
      Russia.
FAU - Basantsova, Natalia
AU  - Basantsova N
AD  - Saint Petersburg State University, Saint Petersburg, Russia.
AD  - Saint Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg, 
      Russia.
FAU - Mayevskaya, Vera
AU  - Mayevskaya V
AD  - Saint Petersburg University of Economics, Saint Petersburg, Russia.
FAU - Yablonskiy, Piotr
AU  - Yablonskiy P
AD  - Saint Petersburg State University, Saint Petersburg, Russia.
AD  - Saint Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg, 
      Russia.
FAU - Shoenfeld, Yehuda
AU  - Shoenfeld Y
AD  - Saint Petersburg State University, Saint Petersburg, Russia.
AD  - Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, 
      Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200811
PL  - England
TA  - ERJ Open Res
JT  - ERJ open research
JID - 101671641
PMC - PMC7418820
COIS- Conflict of interest: A. Malkova has nothing to disclose. Conflict of interest: 
      A. Starshinova has nothing to disclose. Conflict of interest: Y. Zinchenko has 
      nothing to disclose. Conflict of interest: N. Basantsova has nothing to disclose. 
      Conflict of interest: V.A. Mayevskaya has nothing to disclose. Conflict of 
      interest: P. Yablonskiy has nothing to disclose. Conflict of interest: Y. 
      Shoenfeld has nothing to disclose.
EDAT- 2020/08/18 06:00
MHDA- 2020/08/18 06:01
PMCR- 2020/08/11
CRDT- 2020/08/18 06:00
PHST- 2019/12/10 00:00 [received]
PHST- 2020/05/13 00:00 [accepted]
PHST- 2020/08/18 06:00 [entrez]
PHST- 2020/08/18 06:00 [pubmed]
PHST- 2020/08/18 06:01 [medline]
PHST- 2020/08/11 00:00 [pmc-release]
AID - 00155-2020 [pii]
AID - 10.1183/23120541.00155-2020 [doi]
PST - epublish
SO  - ERJ Open Res. 2020 Aug 11;6(3):00155-2020. doi: 10.1183/23120541.00155-2020. 
      eCollection 2020 Jul.